TBC1D32
Protein broad-minded
Protein Summary
Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). This gene encodes a TBC-domain containing protein. Studies of a similar protein in mouse and zebrafish suggest that the encoded protein is involved in sonic hedgehog signaling, and that it interacts with and stabilizes cell cycle-related kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
- ENST00000275159
- ENSP00000275159
- ENSG00000146350
- ENST00000398212
- ENSP00000381270
- ENST00000464622
- ENSP00000428839
- BROMI
- C6orf170
- C6orf171
- BROMI
- C6orf170
- C6orf171
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.93 | ||
histone modification site profile | 0.9 | ||
tissue sample | 0.65 | ||
microRNA | 0.59 | ||
transcription factor | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.85 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 58 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.85 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 58 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0