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Tbio
TBC1D32
Protein broad-minded

Protein Summary
Description
Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling (By similarity). This gene encodes a TBC-domain containing protein. Studies of a similar protein in mouse and zebrafish suggest that the encoded protein is involved in sonic hedgehog signaling, and that it interacts with and stabilizes cell cycle-related kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275159
  • ENSP00000275159
  • ENSG00000146350
  • ENST00000398212
  • ENSP00000381270
  • ENST00000464622
  • ENSP00000428839

Symbol
  • BROMI
  • C6orf170
  • C6orf171
  • BROMI
  • C6orf170
  • C6orf171
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
histone modification site profile
0.9
tissue sample
0.65
microRNA
0.59
transcription factor
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
FOXJ1
Tbio
Family:  TF
Novelty:  0.00778536
p_int:  0.999999984
p_ni:  1.4e-8
p_wrong:  2e-9
Score:  0.374
Data Source:  BioPlex,STRINGDB
CFAP20
Tbio
Novelty:  0.01299681
p_int:  0.999999968
p_ni:  9e-9
p_wrong:  2.3e-8
Score:  0.852
Data Source:  BioPlex,STRINGDB
FAM149B1
Tdark
Novelty:  0.87415255
p_int:  0.99999989
p_ni:  1.07e-7
p_wrong:  4e-9
Score:  0.912
Data Source:  BioPlex,STRINGDB
SLC9A6
Tbio
Family:  Transporter
Novelty:  0.01410234
p_int:  0.999953709
p_ni:  0.000035251
p_wrong:  0.00001104
Score:  0.173
Data Source:  BioPlex,STRINGDB
CDK7
Tchem
Family:  Kinase
Novelty:  0.00322814
p_int:  0.999839557
p_ni:  0.000160425
p_wrong:  1.8e-8
Score:  0.362
Data Source:  BioPlex,STRINGDB
SFSWAP
Tdark
Novelty:  0.2236256
p_int:  0.998402108
p_ni:  0.000574014
p_wrong:  0.001023878
Data Source:  BioPlex
WDPCP
Tbio
Novelty:  0.08368435
Score:  0.759
Data Source:  STRINGDB
CDK20
Tbio
Family:  Kinase
Novelty:  0.01176977
Score:  0.712
Data Source:  STRINGDB
CTDSPL2
Tbio
Family:  Enzyme
Novelty:  0.23254058
Score:  0.634
Data Source:  STRINGDB
PRICKLE1
Tbio
Novelty:  0.03175916
Score:  0.611
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.8
1.5
heart rate
1
1
1
1.4
risk-taking behaviour
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.8
1.5
heart rate
1
1.4
risk-taking behaviour
1
1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 32
VGNC:3724
472114
Macaque
TBC1 domain family member 32
714447
Mouse
MGI:2442827
544696
Rat
RGD:2323599
100359595
Dog
TBC1 domain family member 32
VGNC:47148
484107
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 32
Macaque
TBC1 domain family member 32
Mouse
Rat
Dog
TBC1 domain family member 32
Publication Statistics
PubMed Score 4.03
PubMed score by year
PubTator Score 2.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title