Tbio TBC1D30 TBC1 domain family member 30

Protein Summary

Description

GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro.

Uniprot Accession IDs

• Q9Y2I9
• B3KP01
• B9A6M9
• E7EMW4
• F5GYJ9

Gene Name

• TBC1D30

Ensembl ID

• ENST00000539867
• ENSP00000440207
• ENSG00000111490

Symbol

• KIAA0984

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.72
microRNA	0.68
cell line	0.52
molecular function	0.49
tissue sample	0.49

Protein Classes

PANTHER Classes

Protein / Hydrolase / Tbc1 Domain Family Member 30

Protein / Enzyme Modulator / G-protein Modulator / Tbc1 Domain Family Member 30

Protein / ... / Cysteine Protease / Tbc1 Domain Family Member 30

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Tbc1 Domain Family Member 30

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.73   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.73   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0