Tdark TBC1D2B TBC1 domain family member 2B

Protein Summary

Description

May act as a GTPase-activating protein.

Uniprot Accession IDs

• Q9UPU7
• A7MD42
• Q8N1F9
• Q9NXM0

Gene Name

• TBC1D2B

Ensembl ID

• ENST00000300584
• ENSP00000300584
• ENSG00000167202
• ENST00000409931
• ENSP00000387165

Symbol

• KIAA1055

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.81
cell line	0.6
tissue sample	0.59
disease perturbation	0.56
microRNA	0.56

Protein Classes

PANTHER Classes

Protein / Hydrolase / Tbc1 Domain Family Member 2b

Protein / Enzyme Modulator / G-protein Modulator / Tbc1 Domain Family Member 2b

Protein / ... / Cysteine Protease / Tbc1 Domain Family Member 2b

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Tbc1 Domain Family Member 2b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.74   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 33   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.74   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0