TBC1D25
TBC1 domain family member 25
Protein Summary
Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jan 2017]
- ENST00000376771
- ENSP00000365962
- ENSG00000068354
- ENST00000481090
- ENSP00000476787
- OATL1
- MG81
- OATL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.81 | ||
kinase perturbation | 0.54 | ||
transcription factor binding site profile | 0.54 | ||
tissue | 0.52 | ||
tissue sample | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.31 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 36 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.31 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 36 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0