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Tbio
TBC1D22B
TBC1 domain family member 22B

Protein Summary
Description
May act as a GTPase-activating protein for Rab family protein(s).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373491
  • ENSP00000362590
  • ENSG00000065491

Symbol
  • C6orf197
  • C6orf197
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
tissue sample
0.72
histone modification site profile
0.63
transcription factor binding site profile
0.61
microRNA
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.38   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.38   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (130)
TBC1D22A
Tbio
Novelty:  0.46374046
p_int:  0.999999996
p_wrong:  4e-9
Data Source:  BioPlex
CD207
Tbio
Novelty:  0.00313729
p_int:  0.99999961
p_ni:  3.78e-7
p_wrong:  1.2e-8
Data Source:  BioPlex
A2ML1
Tbio
Novelty:  0.05923067
p_int:  0.99999713
p_ni:  0.000002868
p_wrong:  2e-9
Data Source:  BioPlex
S100A7A
Tbio
Novelty:  0.06518939
p_int:  0.999992868
p_ni:  3.51e-7
p_wrong:  0.000006782
Data Source:  BioPlex
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
p_int:  0.999989734
p_ni:  0.000010223
p_wrong:  4.3e-8
Data Source:  BioPlex
SDR16C5
Tbio
Family:  Enzyme
Novelty:  0.11319496
p_int:  0.999982426
p_ni:  0.000017565
p_wrong:  8e-9
Score:  0.151
Data Source:  BioPlex,STRINGDB
SULT2B1
Tbio
Family:  Enzyme
Novelty:  0.02652128
p_int:  0.999978021
p_ni:  0.000021973
p_wrong:  6e-9
Data Source:  BioPlex
KLK7
Tchem
Family:  Enzyme
Novelty:  0.00757766
p_int:  0.999974421
p_ni:  0.000025579
Data Source:  BioPlex
KLK10
Tbio
Family:  Enzyme
Novelty:  0.00899521
p_int:  0.999962421
p_ni:  0.000037579
p_wrong:  1e-9
Data Source:  BioPlex
PPL
Tbio
Novelty:  0.00684645
p_int:  0.999952137
p_ni:  0.000047863
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
65.8
platelet count
2
2
2
62
mean reticulocyte volume
1
2
2
59.4
red blood cell distribution width
2
1
2
50.5
platelet crit
2
1
2
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
65.8
platelet count
2
62
mean reticulocyte volume
2
59.4
red blood cell distribution width
2
50.5
platelet crit
2
7.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 22B
VGNC:3723
471996
Macaque
TBC1 domain family member 22B
719357
Mouse
MGI:2681867
381085
Rat
RGD:1564987
502414
Dog
TBC1 domain family member 22B
VGNC:47142
481773
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 22B
Macaque
TBC1 domain family member 22B
Mouse
Rat
Dog
TBC1 domain family member 22B
Publication Statistics
PubMed Score 6.38
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
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PMID
Year
Title