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Tbio
TBC1D22A
TBC1 domain family member 22A

Protein Summary
Description
May act as a GTPase-activating protein for Rab family protein(s).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337137
  • ENSP00000336724
  • ENSG00000054611
  • ENST00000355704
  • ENSP00000347932
  • ENST00000406733
  • ENSP00000385634
  • ENST00000441162
  • ENSP00000406214

Symbol
  • C22orf4
  • C22orf4
  • HSC79E021
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.97
transcription factor binding site profile
0.89
kinase perturbation
0.81
histone modification site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.77   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.77   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999999996
p_wrong:  4e-9
Data Source:  BioPlex
SUPT6H
Tbio
Novelty:  0.01099565
p_int:  0.996525824
p_ni:  0.003474176
Data Source:  BioPlex
EFNB3
Tbio
Novelty:  0.0120367
p_int:  0.994977193
p_ni:  0.0050228
p_wrong:  7e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
MICU2
Tbio
Novelty:  0.04146208
p_int:  0.992635611
p_ni:  0.007364388
Score:  0.562
Data Source:  BioPlex,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.992244291
p_ni:  0.007755709
Score:  0.154
Data Source:  BioPlex,STRINGDB
DNAJB5
Tbio
Novelty:  0.20703358
p_int:  0.990192766
p_ni:  0.009639748
p_wrong:  0.000167486
Score:  0.536
Data Source:  BioPlex,STRINGDB
EXOG
Tbio
Family:  Enzyme
Novelty:  0.03588463
p_int:  0.986155221
p_ni:  0.013290867
p_wrong:  0.000553913
Score:  0.196
Data Source:  BioPlex,STRINGDB
KIRREL1
Tbio
Novelty:  0.03216031
p_int:  0.972192992
p_ni:  0.027807008
Data Source:  BioPlex
MICU1
Tbio
Novelty:  0.00984731
p_int:  0.962832668
p_ni:  0.037167332
Score:  0.671
Data Source:  BioPlex,STRINGDB
ACBD3
Tbio
Novelty:  0.02992688
p_int:  0.943646996
p_ni:  0.056353004
Score:  0.851
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical thickness
2
2
1
7.4
88
functional brain measurement
1
1
0
7
70.6
language measurement
1
1
0
7
70.6
ceramide measurement
5
1
5
66.2
brain measurement
1
1
0
8.1
55.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical thickness
1
7.4
88
functional brain measurement
0
7
70.6
language measurement
0
7
70.6
ceramide measurement
5
66.2
brain measurement
0
8.1
55.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 22A
VGNC:6003
458922
Macaque
TBC1 domain family member 22A-like
719018
Mouse
MGI:1289265
223754
Rat
RGD:1306588
689443
Dog
TBC1 domain family member 22A
VGNC:47141
474462
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 22A
Macaque
TBC1 domain family member 22A-like
Mouse
Rat
Dog
TBC1 domain family member 22A
Publication Statistics
PubMed Score 4.77
PubMed score by year
PubTator Score 2.67
PubTator score by year
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Related Publications
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PMID
Year
Title