Tdark TBC1D21 TBC1 domain family member 21

Protein Summary

Description

May act as a GTPase-activating protein for Rab family protein(s) (PubMed:19077034). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978).

Uniprot Accession IDs

• Q8IYX1
• B9A6M2

Gene Name

• TBC1D21

Ensembl ID

• ENST00000300504
• ENSP00000300504
• ENSG00000167139
• ENST00000535547
• ENSP00000439325

Symbol

• MgcRabGAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
cell type or tissue	0.78
cellular component	0.65
molecular function	0.56
disease perturbation	0.49

Protein Classes

PANTHER Classes

Protein / Hydrolase / Tbc1 Domain Family Member 21

Protein / Enzyme Modulator / G-protein Modulator / Tbc1 Domain Family Member 21

Protein / ... / Cysteine Protease / Tbc1 Domain Family Member 21

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Tbc1 Domain Family Member 21

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0