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Tchem
TASP1
Threonine aspartase 1

Protein Summary
Description
Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster. This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337743
  • ENSP00000338624
  • ENSG00000089123

Symbol
  • C20orf13
  • C20orf13
  • dJ585I14.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.76
transcription factor perturbation
0.74
transcription factor binding site profile
0.68
tissue sample
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.56   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.56   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (29)
ASPG
Tbio
Family:  Enzyme
Novelty:  0.00338263
Score:  0.835
Data Source:  STRINGDB
KMT2A
Tchem
Family:  Epigenetic
Novelty:  0.00192554
Score:  0.779
Data Source:  STRINGDB
ZBTB34
Tdark
Family:  TF
Novelty:  0.5693361
Score:  0.704
Data Source:  STRINGDB
GTF2A1
Tchem
Novelty:  0.19577296
Score:  0.681
Data Source:  STRINGDB
KMT2B
Tbio
Family:  Epigenetic
Novelty:  0.00593529
Score:  0.668
Data Source:  STRINGDB
POLR1B
Tbio
Family:  Enzyme
Novelty:  0.06955307
Score:  0.663
Data Source:  STRINGDB
GZF1
Tbio
Family:  TF
Novelty:  0.15337347
Score:  0.613
Data Source:  STRINGDB
HCFC1
Tbio
Novelty:  0.00440762
Score:  0.593
Data Source:  STRINGDB
THOC1
Tbio
Novelty:  0.03702557
Score:  0.59
Data Source:  STRINGDB
NPM1
Tbio
Novelty:  0.0005485
Score:  0.587
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ceramide measurement
21
10
31
94.7
sphingomyelin measurement
15
74
312
94.7
genotoxic compound exposure measurement
3
30
53
93.2
phosphatidylcholine measurement
2
39
39
86.6
osteocalcin measurement
1
26
26
86.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ceramide measurement
31
94.7
sphingomyelin measurement
312
94.7
genotoxic compound exposure measurement
53
93.2
phosphatidylcholine measurement
39
86.6
osteocalcin measurement
26
86.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taspase 1
VGNC:14306
735437
Macaque
taspase 1
694028
Mouse
MGI:1923062
75812
Rat
RGD:1308591
311468
Dog
taspase 1
VGNC:47122
477152
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taspase 1
Macaque
taspase 1
Mouse
Rat
Dog
taspase 1
Publication Statistics
PubMed Score 45.56
PubMed score by year
PubTator Score 22.77
PubTator score by year
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Related Publications
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PMID
Year
Title