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Tchem
TAS2R7
Taste receptor type 2 member 7

Protein Summary
Description
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240687
  • ENSP00000240687
  • ENSG00000121377
  • ENST00000574656
  • ENSP00000458498
  • ENSG00000273326
  • ENST00000613239
  • ENSP00000484743
  • ENSG00000274327

Symbol
  • T2R7
  • TRB4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.53
cell type or tissue
0.53
metabolite
0.45
protein domain
0.41
tissue
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.83   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.83   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (251)
MVB12A
Tbio
Novelty:  0.09794
p_int:  0.998501429
p_ni:  0.001498565
p_wrong:  5e-9
Score:  0.207
Data Source:  BioPlex,STRINGDB
MICAL1
Tbio
Family:  Enzyme
Novelty:  0.02668048
p_int:  0.996173199
p_ni:  0.003798204
p_wrong:  0.000028597
Score:  0.224
Data Source:  BioPlex,STRINGDB
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.995636276
p_ni:  0.004359735
p_wrong:  0.000003989
Data Source:  BioPlex
INTS12
Tbio
Family:  Epigenetic
Novelty:  0.09023473
p_int:  0.970163694
p_ni:  0.029834473
p_wrong:  0.000001834
Score:  0.181
Data Source:  BioPlex,STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.95568877
p_ni:  0.044311209
p_wrong:  2.1e-8
Data Source:  BioPlex
CD2AP
Tbio
Novelty:  0.00603034
p_int:  0.921709058
p_ni:  0.078290942
Score:  0.207
Data Source:  BioPlex,STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
p_int:  0.913081811
p_ni:  0.086918185
p_wrong:  3e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
p_int:  0.895591786
p_ni:  0.104408204
p_wrong:  1e-8
Data Source:  BioPlex
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.841278354
p_ni:  0.158721646
Data Source:  BioPlex
GNAQ
Tbio
Novelty:  0.0008997
p_int:  0.801767908
p_ni:  0.198228374
p_wrong:  0.000003718
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

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Find Similar Targets
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1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
6.5
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 7
107967742
Mouse
MGI:2681278
387355
Rat
RGD:1597354
690334
Dog
taste 2 receptor member 7
VGNC:47121
100271739
Horse
taste 2 receptor member 7
106783277
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 7
Mouse
Rat
Dog
taste 2 receptor member 7
Horse
taste 2 receptor member 7
Publication Statistics
PubMed Score 11.83
PubMed score by year
PubTator Score 4.38
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title