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Tchem
TAS2R16
Taste receptor type 2 member 16

Protein Summary
Description
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249284
  • ENSP00000249284
  • ENSG00000128519

Symbol
  • BGLPT
  • T2R16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.58
cell line
0.53
metabolite
0.45
disease perturbation
0.43
cellular component
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.18   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.18   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (262)
TAS2R38
Tchem
Family:  GPCR
Novelty:  0.004625
Score:  0.985
Data Source:  STRINGDB
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
Score:  0.962
Data Source:  STRINGDB
P2RY13
Tchem
Family:  GPCR
Novelty:  0.01511227
Score:  0.96
Data Source:  STRINGDB
TAS1R2
Tbio
Family:  GPCR
Novelty:  0.00568766
Score:  0.957
Data Source:  STRINGDB
TAS1R1
Tbio
Family:  GPCR
Novelty:  0.00913004
Score:  0.957
Data Source:  STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.956
Data Source:  STRINGDB
CHRM2
Tclin
Family:  GPCR
Novelty:  0.00326718
Score:  0.954
Data Source:  STRINGDB
CASR
Tclin
Family:  GPCR
Novelty:  0.00061316
Score:  0.953
Data Source:  STRINGDB
TAS1R3
Tbio
Family:  GPCR
Novelty:  0.00370936
Score:  0.95
Data Source:  STRINGDB
OPRK1
Tclin
Family:  GPCR
Novelty:  0.00171044
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 16
VGNC:8769
494113
Mouse
MGI:2681247
387347
Rat
RGD:620735
78980
Cow
taste 2 receptor member 16
VGNC:35610
664638
Opossum
bitter taste receptor Modo-T2R62
664658
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 16
Mouse
Rat
Cow
taste 2 receptor member 16
Opossum
bitter taste receptor Modo-T2R62
Publication Statistics
PubMed Score 35.18
PubMed score by year
PubTator Score 23.57
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title