Tchem TAS2R14 Taste receptor type 2 member 14

Protein Summary

Description

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NYV8
• Q645X3
• T2R14

Gene Name

• TAS2R14

Ensembl ID

• ENST00000537503
• ENSP00000441949
• ENSG00000212127
• ENST00000575008
• ENSP00000458544
• ENSG00000261984
• ENST00000614274
• ENSP00000484251
• ENSG00000276541

Symbol

• TRB1
• T2R14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.8
cell line	0.57
tissue sample	0.56
tissue	0.52
chemical	0.42

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Taste 2 Receptor / Taste Receptor Type 2 Member 14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.43   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 74   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.43   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1