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Tbio
TARSL2
Threonine--tRNA ligase 2, cytoplasmic

Protein Summary
Description
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335968
  • ENSP00000338093
  • ENSG00000185418
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.9
histone modification site profile
0.72
transcription factor perturbation
0.68
tissue sample
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.05   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.05   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
CCDC102B
Tdark
Novelty:  0.28075569
p_int:  0.999998986
p_ni:  0.000001014
Data Source:  BioPlex
AIMP1
Tbio
Family:  Enzyme
Novelty:  0.00743447
p_int:  0.999994292
p_ni:  0.000005708
Score:  0.931
Data Source:  BioPlex,STRINGDB
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
p_int:  0.999993971
p_ni:  0.000006029
Score:  0.969
Data Source:  BioPlex,STRINGDB
ING2
Tchem
Family:  Epigenetic
Novelty:  0.02424031
p_int:  0.999989418
p_ni:  0.000010582
Data Source:  BioPlex
SDCBP
Tbio
Novelty:  0.00242211
p_int:  0.999942988
p_ni:  0.000057012
Score:  0.524
Data Source:  BioPlex,STRINGDB
LARS
Tchem
Family:  Enzyme
Novelty:  0.00361711
p_int:  0.99992882
p_ni:  0.00007118
Score:  0.982
Data Source:  BioPlex,STRINGDB
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
p_int:  0.999395206
p_ni:  0.000604794
Score:  0.881
Data Source:  BioPlex,STRINGDB
BATF3
Tbio
Family:  TF
Novelty:  0.01554987
p_int:  0.99938682
p_ni:  0.000613118
p_wrong:  6.2e-8
Data Source:  BioPlex
RASSF7
Tbio
Novelty:  0.08011259
p_int:  0.996725131
p_ni:  0.003274869
Data Source:  BioPlex
NMI
Tbio
Novelty:  0.06987427
p_int:  0.994357227
p_ni:  0.005642773
Score:  0.234
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
threonyl-tRNA synthetase like 2
VGNC:6590
453695
Macaque
threonyl-tRNA synthetase like 2
698423
Mouse
MGI:2444486
272396
Dog
threonyl-tRNA synthetase like 2
VGNC:47111
479019
Horse
threonyl-tRNA synthetase like 2
VGNC:23878
100057955
Species
Name
OMA
EggNOG
Inparanoid
Chimp
threonyl-tRNA synthetase like 2
Macaque
threonyl-tRNA synthetase like 2
Mouse
Dog
threonyl-tRNA synthetase like 2
Horse
threonyl-tRNA synthetase like 2
Publication Statistics
PubMed Score 34.05
PubMed score by year
PubTator Score 5.58
PubTator score by year
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Related Publications
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PMID
Year
Title