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Tchem
TARS
Threonine--tRNA ligase, cytoplasmic

Protein Summary
Description
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity). Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265112
  • ENSP00000265112
  • ENSG00000113407
  • ENST00000455217
  • ENSP00000387710
  • ENST00000502553
  • ENSP00000424387

Symbol
  • ThrRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
disease perturbation
0.98
interacting protein
0.98
molecular function
0.94
virus perturbation
0.94


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.3   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.3   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (170)
EIF4E2
Tbio
Novelty:  0.0490219
p_int:  0.789477398
p_ni:  0.210522602
Score:  0.243
Data Source:  BioPlex,STRINGDB
CCDC102B
Tbio
Novelty:  0.28075569
p_int:  0.776209594
p_ni:  0.223790406
Score:  0.189
Data Source:  BioPlex,STRINGDB
GARS
Tchem
Family:  Enzyme
Novelty:  0.00190498
Score:  0.984
Data Source:  STRINGDB
SARS
Tbio
Family:  Enzyme
Novelty:  0.00963508
Score:  0.972
Data Source:  STRINGDB
IARS
Tchem
Family:  Enzyme
Novelty:  0.00539046
Score:  0.964
Data Source:  STRINGDB
NARS
Tbio
Family:  Enzyme
Novelty:  0.01124207
Score:  0.958
Data Source:  STRINGDB
YARS
Tchem
Family:  Enzyme
Novelty:  0.00302115
Score:  0.956
Data Source:  STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
Score:  0.954
Data Source:  STRINGDB
MARS
Tchem
Family:  Enzyme
Novelty:  0.01318702
Score:  0.951
Data Source:  STRINGDB
HARS
Tchem
Family:  Enzyme
Novelty:  0.01271582
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism of proteins
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism of proteins
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
52.9
BMI-adjusted waist circumference
1
1
1
30.9
vital capacity
1
1
1
21.2
forced expiratory volume
1
1
1
16.3
appendicular lean mass
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
52.9
BMI-adjusted waist circumference
1
30.9
vital capacity
1
21.2
forced expiratory volume
1
16.3
appendicular lean mass
1
10.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
threonyl-tRNA synthetase
VGNC:4188
461951
Mouse
MGI:106314
110960
Rat
RGD:1359527
294810
Dog
threonyl-tRNA synthetase
VGNC:47110
479370
Horse
threonyl-tRNA synthetase
VGNC:23877
100068323
Species
Name
OMA
EggNOG
Inparanoid
Chimp
threonyl-tRNA synthetase
Mouse
Rat
Dog
threonyl-tRNA synthetase
Horse
threonyl-tRNA synthetase
Publication Statistics
PubMed Score 163.30
PubMed score by year
PubTator Score 45.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title