You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TARBP1
Probable methyltransferase TARBP1

Protein Summary
Description
Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA. HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR duri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000040877
  • ENSP00000040877
  • ENSG00000059588

Symbol
  • TRM3
  • TRP185
  • TRM3
  • TRMT3
  • TRP185
  • TRP-185
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
kinase perturbation
0.66
histone modification site profile
0.64
trait
0.61
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.4   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.4   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
BSG
Tbio
Novelty:  0.0010285
p_int:  0.99999401
p_ni:  0.00000599
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.999974608
p_ni:  0.000025392
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.999957505
p_ni:  0.000042493
p_wrong:  2e-9
Data Source:  BioPlex
TNFRSF17
Tclin
Novelty:  0.00222663
p_int:  0.999686467
p_ni:  0.000313533
Score:  0.213
Data Source:  BioPlex,STRINGDB
DLK2
Tbio
Novelty:  0.06366405
p_int:  0.998521272
p_ni:  0.001478728
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.9984207
p_ni:  0.001579298
p_wrong:  2e-9
Data Source:  BioPlex
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
p_int:  0.998394465
p_ni:  0.001605535
Score:  0.161
Data Source:  BioPlex,STRINGDB
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.997471086
p_ni:  0.002528909
p_wrong:  5e-9
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.994402601
p_ni:  0.005597399
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.993879726
p_ni:  0.006120157
p_wrong:  1.17e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
7.6
response to anticonvulsant
1
1
0
4.5
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
7.6
response to anticonvulsant
0
4.5
0.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TAR (HIV-1) RNA binding protein 1
457830
Macaque
TAR (HIV-1) RNA binding protein 1
712397
Mouse
MGI:4936930
212728
Dog
TAR (HIV-1) RNA binding protein 1
479200
Horse
TAR (HIV-1) RNA binding protein 1
100059375
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TAR (HIV-1) RNA binding protein 1
Macaque
TAR (HIV-1) RNA binding protein 1
Mouse
Dog
TAR (HIV-1) RNA binding protein 1
Horse
TAR (HIV-1) RNA binding protein 1
Publication Statistics
PubMed Score 21.40
PubMed score by year
PubTator Score 10.78
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title