Protein Summary
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000374572
- ENSP00000363700
- ENSG00000112493
- ENST00000383066
- ENSP00000372543
- ENSG00000206208
- ENST00000383197
- ENSP00000372684
- ENSG00000206281
- ENST00000383198
- ENSP00000372685
- ENST00000395114
- ENSP00000378546
- ENST00000417059
- ENSP00000402087
- ENSG00000236490
- ENST00000434618
- ENSP00000395701
- ENSG00000231925
- ENST00000456807
- ENSP00000407195
- NGS17
- TAPA
- TPN
- TAPA
- TPSN
- NGS17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.98 | ||
molecular function | 0.98 | ||
cellular component | 0.85 | ||
PubMedID | 0.85 | ||
kinase perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 347.78 (req: < 5)
Gene RIFs: 50 (req: <= 3)
Antibodies: 190 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 347.78 (req: >= 5)
Gene RIFs: 50 (req: > 3)
Antibodies: 190 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (140)
HLA-DQB1
Novelty: 0.00197952
p_int: 0.999993769
p_ni: 0.000006177
p_wrong: 5.4e-8
Score: 0.24
Data Source: BioPlex,STRINGDB
HFE
Novelty: 0.00042077
p_int: 0.999987165
p_ni: 0.000010476
p_wrong: 0.00000236
Score: 0.288
Data Source: BioPlex,STRINGDB
HTR2C
Family: GPCR
Novelty: 0.00074287
p_int: 0.999957335
p_ni: 0.000040389
p_wrong: 0.000002276
Score: 0.189
Data Source: BioPlex,STRINGDB
CHRNB4
Family: IC
Novelty: 0.01151716
p_int: 0.999501968
p_ni: 0.000222773
p_wrong: 0.000275259
Data Source: BioPlex
Nearest Tclin Targets
Pathways (11)
Reactome (6)
KEGG (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | ER-Phagosome pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen Presentation: Folding, assembly and peptide loading of class I MHC | ||||
Antigen processing-Cross presentation | ||||
Class I MHC mediated antigen processing & presentation | ||||
ER-Phagosome pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (7)
Components (8)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (50)
Items per page:
1 – 5 of 50
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
body mass index | 1 | 1 | 1 | 63.4 | ||||||
body mass index | 1 | 1 | 1 | 63.4 | ||||||
body mass index | 1 | 1 | 1 | 63.4 | ||||||
body mass index | 1 | 1 | 1 | 63.4 | ||||||
body mass index | 1 | 1 | 1 | 63.4 | ||||||
Items per page:
1 – 5 of 50
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body mass index | 1 | 63.4 | |||||
body mass index | 1 | 63.4 | |||||
body mass index | 1 | 63.4 | |||||
body mass index | 1 | 63.4 | |||||
body mass index | 1 | 63.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | TAP binding protein | 718235 | ||||||
Mouse | MGI:1201689 | 21356 | ||||||
Rat | RGD:3819 | 25217 | ||||||
Dog | TAP binding protein | VGNC:47106 | 481740 | |||||
Horse | TAP binding protein | VGNC:23872 | 100061515 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | TAP binding protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | TAP binding protein | |||||
Horse | TAP binding protein | |||||
Publication Statistics
PubMed Score 347.78
PubMed score by year
PubTator Score 217.68
PubTator score by year
Related Publications
Text Mined References (88)
GeneRif Annotations (50)
Items per page:
0 of 0
PMID | Year | Title |
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