Tbio TAPBP Tapasin

Protein Summary

Description

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15533
• A2AB91
• A2ABC0
• B0V003
• B0V0A6
• B2ZUA4
• E9PGM2
• O15210
• O15272
• Q5STJ8
• Q5STK6
• Q5STQ5
• Q5STQ6
• Q66K65
• Q96KK7
• Q9HAN8
• Q9UEE0
• Q9UEE4
• Q9UIZ6
• Q9Y6K2
• TPN

Gene Name

• TAPBP

Ensembl ID

• ENST00000374572
• ENSP00000363700
• ENSG00000112493
• ENST00000383066
• ENSP00000372543
• ENSG00000206208
• ENST00000383197
• ENSP00000372684
• ENSG00000206281
• ENST00000383198
• ENSP00000372685
• ENST00000395114
• ENSP00000378546
• ENST00000417059
• ENSP00000402087
• ENSG00000236490
• ENST00000434618
• ENSP00000395701
• ENSG00000231925
• ENST00000456807
• ENSP00000407195

Symbol

• NGS17
• TAPA
• TPN
• TAPA
• TPSN
• NGS17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
molecular function	0.98
cellular component	0.85
PubMedID	0.85
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Tapasin

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Tapasin

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Tapasin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.78   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 190   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.78   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (140)

Explore Interacting Targets

1 – 10 of 140

• See Interactions on String-DB

HLA-DQB1

Tbio

Novelty:  0.00197952

p_int:  0.999993769

p_ni:  0.000006177

p_wrong:  5.4e-8

Score:  0.24

Data Source:  BioPlex,STRINGDB

HFE

Tbio

Novelty:  0.00042077

p_int:  0.999987165

p_ni:  0.000010476

p_wrong:  0.00000236

Score:  0.288

Data Source:  BioPlex,STRINGDB

HTR2C

Tclin

Family:  GPCR

Novelty:  0.00074287

p_int:  0.999957335

p_ni:  0.000040389

p_wrong:  0.000002276

Score:  0.189

Data Source:  BioPlex,STRINGDB

CHRNB4

Tclin

Family:  IC

Novelty:  0.01151716

p_int:  0.999501968

p_ni:  0.000222773

p_wrong:  0.000275259

Data Source:  BioPlex

PDIA3

Tbio

Family:  Enzyme

Novelty:  0.00285939

Score:  0.997

Data Source:  STRINGDB

B2M

Tbio

Novelty:  0.00011248

Score:  0.994

Data Source:  STRINGDB

TAP2

Tbio

Novelty:  0.0390555

Score:  0.991

Data Source:  Reactome,STRINGDB

TAP1

Tbio

Novelty:  0.02264011

Score:  0.986

Data Source:  Reactome,STRINGDB

CALR

Tbio

Novelty:  0.0004479

Score:  0.984

Data Source:  Reactome,STRINGDB

P30456

Tbio

Novelty:  0.00270731

Score:  0.981

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (6)

KEGG (5)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	92 targets	R-HSA-983170
Reactome	Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Reactome	ER-Phagosome pathway	153 targets	R-HSA-1236974

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	92 targets	R-HSA-983170
Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
ER-Phagosome pathway	153 targets	R-HSA-1236974

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (25)

Functions (7)

Components (8)

Processes (10)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
TAP complex binding	Inferred from Direct Assay (IDA)	UniProtKB
TAP1 binding	Inferred from Physical Interaction (IPI)	UniProtKB
TAP2 binding	Inferred from Physical Interaction (IPI)	UniProtKB
MHC class I protein binding	Traceable Author Statement (TAS)	UniProtKB
peptide antigen binding	Traceable Author Statement (TAS)	UniProtKB
peptide antigen-transporting ATPase activity	Traceable Author Statement (TAS)	ProtInc
unfolded protein binding	Traceable Author Statement (TAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (50)

Items per page:

5

1 – 5 of 50

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	ENSG00000112493	1	1	1		63.4
body mass index	EFO_0004340	ENSG00000206281	1	1	1		63.4
body mass index	EFO_0004340	ENSG00000236490	1	1	1		63.4
body mass index	EFO_0004340	ENSG00000206208	1	1	1		63.4
body mass index	EFO_0004340	ENSG00000231925	1	1	1		63.4

Items per page:

5

1 – 5 of 50

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	1		63.4
body mass index	EFO_0004340	1		63.4
body mass index	EFO_0004340	1		63.4
body mass index	EFO_0004340	1		63.4
body mass index	EFO_0004340	1		63.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Immunoglobulin domain
Membrane
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
autism spectrum disorder
body height
body mass index
cervical carcinoma
gait measurement
schizophrenia
self reported educational attainment
smoking status measurement
triple-negative breast cancer
visceral adipose tissue measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	TAP binding protein		718235
Mouse	TAP binding protein	MGI:1201689	21356
Rat	TAP binding protein	RGD:3819	25217
Dog	TAP binding protein	VGNC:47106	481740
Horse	TAP binding protein	VGNC:23872	100061515

Species	Name	OMA	EggNOG	Inparanoid
Macaque	TAP binding protein
Mouse	TAP binding protein
Rat	TAP binding protein
Dog	TAP binding protein
Horse	TAP binding protein

Publication Statistics

PubMed Score 347.78

PubMed score by year

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PubTator Score 217.68

PubTator score by year

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Related Publications

Text Mined References (88)

GeneRif Annotations (50)

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PMID	Year	Title