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Tbio
TAP2
Antigen peptide transporter 2

Protein Summary
Description
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various m ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374897
  • ENSP00000364032
  • ENSG00000204267
  • ENST00000374899
  • ENSP00000364034
  • ENST00000383118
  • ENSP00000372599
  • ENSG00000206235
  • ENST00000383119
  • ENSP00000372600
  • ENST00000383239
  • ENSP00000372726
  • ENSG00000206299
  • ENST00000383240
  • ENSP00000372727
  • ENST00000414145
  • ENSP00000401377
  • ENSG00000228582
  • ENST00000419142
  • ENSP00000390013
  • ENSG00000237599
  • ENST00000426977
  • ENSP00000387553
  • ENSG00000232326
  • ENST00000439425
  • ENSP00000396156
  • ENSG00000225967
  • ENST00000443713
  • ENSP00000394101
  • ENST00000451907
  • ENSP00000392172
  • ENSG00000223481

Symbol
  • ABCB3
  • PSF2
  • RING11
  • Y1
  • APT2
  • PSF2
  • ABC18
  • ABCB3
  • PSF-2
  • RING11
  • D6S217E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
0.97
protein domain
0.92
interacting protein
0.86
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: < 5)
Gene RIFs: 94   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: >= 5)
Gene RIFs: 94   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
TAP1
Tbio
Novelty:  0.02264011
p_int:  0.999999985
p_ni:  1.2e-8
p_wrong:  3e-9
Score:  0.963
Data Source:  BioPlex,Reactome,STRINGDB
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.999989092
p_ni:  0.000010908
Data Source:  BioPlex
TMCO3
Tdark
Novelty:  1.16719823
p_int:  0.999547599
p_ni:  0.000452317
p_wrong:  8.4e-8
Score:  0.221
Data Source:  BioPlex,STRINGDB
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.999212279
p_ni:  0.000787627
p_wrong:  9.3e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.999034152
p_ni:  0.00096266
p_wrong:  0.000003188
Data Source:  BioPlex
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
p_int:  0.998796151
p_ni:  0.001201232
p_wrong:  0.000002617
Data Source:  BioPlex
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
p_int:  0.998518901
p_ni:  0.001353559
p_wrong:  0.000127541
Score:  0.209
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.995580432
p_ni:  0.004402775
p_wrong:  0.000016794
Score:  0.178
Data Source:  BioPlex,STRINGDB
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.99488063
p_ni:  0.004939719
p_wrong:  0.000179651
Data Source:  BioPlex
PTCHD3
Tbio
Novelty:  0.00081643
p_int:  0.993343047
p_ni:  0.006480205
p_wrong:  0.000176749
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
ER-Phagosome pathway
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
ER-Phagosome pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (360)
Items per page:
1 – 5 of 360
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
2
88.9
3
2
0
2
88.9
3
2
0
2
88.9
3
2
0
2
88.9
3
2
0
2
88.9
Items per page:
1 – 5 of 360
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
88.9
0
2
88.9
0
2
88.9
0
2
88.9
0
2
88.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 18.07
PubMed score by year
PubTator Score 338.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title