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Tbio
TAP1
Antigen peptide transporter 1

Protein Summary
Description
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354258
  • ENSP00000346206
  • ENSG00000168394
  • ENST00000383235
  • ENSP00000372722
  • ENSG00000206297
  • ENST00000414467
  • ENSP00000405356
  • ENSG00000226173
  • ENST00000418205
  • ENSP00000401149
  • ENSG00000227816
  • ENST00000424897
  • ENSP00000413080
  • ENSG00000230705
  • ENST00000439781
  • ENSP00000415660
  • ENSG00000224212
  • ENST00000440894
  • ENSP00000402316
  • ENSG00000232367

Symbol
  • ABCB2
  • PSF1
  • RING4
  • Y3
  • APT1
  • PSF1
  • ABC17
  • ABCB2
  • PSF-1
  • RING4
  • TAP1N
  • D6S114E
  • TAP1*0102N
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
virus perturbation
1
transcription factor perturbation
0.94
protein domain
0.92
biological term
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.55   (req: < 5)
Gene RIFs: 137   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.55   (req: >= 5)
Gene RIFs: 137   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0