Tchem TAOK3 Serine/threonine-protein kinase TAO3

Protein Summary

Description

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q9H2K8
• Q658N1
• Q8IUM4
• Q9HC79
• Q9NZM9
• Q9UHG7

Gene Name

• TAOK3

Ensembl ID

• ENST00000392533
• ENSP00000376317
• ENSG00000135090
• ENST00000419821
• ENSP00000416374

Symbol

• DPK
• JIK
• KDS
• MAP3K18
• DPK
• JIK
• hKFC-A
• MAP3K18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
transcription factor perturbation	0.91
biological process	0.9
virus perturbation	0.9
small molecule	0.89

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Tao Subfamily / Serine/threonine-protein Kinase Tao3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.74   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 358   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.74   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0