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Tbio
TANK
TRAF family member-associated NF-kappa-B activator

Protein Summary
Description
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259075
  • ENSP00000259075
  • ENSG00000136560
  • ENST00000392749
  • ENSP00000376505
  • ENST00000403609
  • ENSP00000385983

Symbol
  • ITRAF
  • TRAF2
  • ITRAF
  • TRAF2
  • I-TRAF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
hub protein
0.85
kinase perturbation
0.71
transcription factor
0.71
tissue sample
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.49   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 440   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.49   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 440   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0