Tbio TALDO1 Transaldolase

Protein Summary

Description

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P37837
• B2R8M2
• O00751
• Q8WV32
• Q8WZ45

Gene Name

• TALDO1

Ensembl ID

• ENST00000319006
• ENSP00000321259
• ENSG00000177156

Symbol

• TAL
• TALDO
• TALDOR
• TAL
• TALH
• TAL-H
• TALDOR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
virus perturbation	0.99
kinase perturbation	0.81
transcription factor binding site profile	0.77
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.09   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.09   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (221)

Explore Interacting Targets

1 – 10 of 221

• See Interactions on String-DB

DENR

Tbio

Novelty:  0.00653432

p_int:  0.954074854

p_ni:  0.045925146

Score:  0.172

Data Source:  BioPlex,STRINGDB

WDR45

Tbio

Novelty:  0.0148072

p_int:  0.951364457

p_ni:  0.048265923

p_wrong:  0.00036962

Score:  0.719

Data Source:  BioPlex,STRINGDB

CFDP1

Tbio

Novelty:  0.02175158

p_int:  0.943149301

p_ni:  0.056721788

p_wrong:  0.00012891

Score:  0.309

Data Source:  BioPlex,STRINGDB

PDE6D

Tclin

Family:  Enzyme

Novelty:  0.02276328

p_int:  0.88931388

p_ni:  0.110686089

p_wrong:  3.1e-8

Score:  0.555

Data Source:  BioPlex,STRINGDB

PMF1

Tbio

Novelty:  0.05319446

p_int:  0.865129225

p_ni:  0.134870742

p_wrong:  3.2e-8

Data Source:  BioPlex

SPC24

Tbio

Novelty:  0.03166479

p_int:  0.778950902

p_ni:  0.221049098

Score:  0.527

Data Source:  BioPlex,STRINGDB

MRC2

Tbio

Novelty:  0.01100289

p_int:  0.772932343

p_ni:  0.227067657

Score:  0.189

Data Source:  BioPlex,STRINGDB

ATG2B

Tbio

Novelty:  0.04963717

p_int:  0.762895117

p_ni:  0.237104682

p_wrong:  2.01e-7

Score:  0.67

Data Source:  BioPlex,STRINGDB

TKT

Tchem

Family:  Enzyme

Novelty:  0.00333936

Score:  0.999

Data Source:  STRINGDB

TKTL2

Tbio

Family:  Enzyme

Novelty:  0.0915871

Score:  0.994

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (37)

Reactome (17)

KEGG (4)

PathwayCommons (4)

UniProt (1)

WikiPathways (11)

Cytokine Signaling in Immune system (R-HSA-1280215)

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5

1 – 5 of 17

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of carbohydrate metabolism	35 targets	R-HSA-5663084
Reactome	Diseases of metabolism	103 targets	R-HSA-5668914
Reactome	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	37 targets	R-HSA-8950505

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Disease	1105 targets	R-HSA-1643685
Diseases of carbohydrate metabolism	35 targets	R-HSA-5663084
Diseases of metabolism	103 targets	R-HSA-5668914
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	37 targets	R-HSA-8950505

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (2)

Components (5)

Processes (6)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	Inferred from Experiment (EXP)	Reactome
monosaccharide binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (15)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 15

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	3	5	6		91.5
mean platelet volume	EFO_0004584	2	2	2		89.4
intraocular pressure measurement	EFO_0004695	2	3	3		89
waist-hip ratio	EFO_0004343	4	6	9		86.9
Keratoconus	Orphanet_156071	2	2	1	6.6	82.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 15

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	6		91.5
mean platelet volume	EFO_0004584	2		89.4
intraocular pressure measurement	EFO_0004695	3		89
waist-hip ratio	EFO_0004343	9		86.9
Keratoconus	Orphanet_156071	1	6.6	82.1

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Disease mutation
Pentose shunt
Phosphoprotein
Reference proteome
Schiff base
Transferase

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body fat distribution
chronic bronchitis
chronic obstructive pulmonary disease
high density lipoprotein cholesterol measurement
hip circumference
intraocular pressure measurement
Keratoconus

MGI Phenotype Find Similar Targets

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cellular phenotype
homeostasis/metabolism phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transaldolase 1	VGNC:991	450933
Mouse	transaldolase 1	MGI:1274789	21351
Rat	transaldolase 1	RGD:620674	83688
Dog	transaldolase		475937
Horse	transaldolase 1	VGNC:23863	100055991

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transaldolase 1
Mouse	transaldolase 1
Rat	transaldolase 1
Dog	transaldolase
Horse	transaldolase 1

Publication Statistics

PubMed Score 484.09

PubMed score by year

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PubTator Score 340.10

PubTator score by year

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Related Publications

Text Mined References (39)

GeneRif Annotations (19)

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PMID	Year	Title