Protein Summary
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
- ENST00000319006
- ENSP00000321259
- ENSG00000177156
- TAL
- TALDO
- TALDOR
- TAL
- TALH
- TAL-H
- TALDOR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.99 | ||
virus perturbation | 0.99 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.77 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 484.09 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 221 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 484.09 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 221 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (221)
DENR
Novelty: 0.00653432
p_int: 0.954074854
p_ni: 0.045925146
Score: 0.172
Data Source: BioPlex,STRINGDB
WDR45
Novelty: 0.0148072
p_int: 0.951364457
p_ni: 0.048265923
p_wrong: 0.00036962
Score: 0.719
Data Source: BioPlex,STRINGDB
CFDP1
Novelty: 0.02175158
p_int: 0.943149301
p_ni: 0.056721788
p_wrong: 0.00012891
Score: 0.309
Data Source: BioPlex,STRINGDB
PDE6D
Family: Enzyme
Novelty: 0.02276328
p_int: 0.88931388
p_ni: 0.110686089
p_wrong: 3.1e-8
Score: 0.555
Data Source: BioPlex,STRINGDB
PMF1
Novelty: 0.05319446
p_int: 0.865129225
p_ni: 0.134870742
p_wrong: 3.2e-8
Data Source: BioPlex
SPC24
Novelty: 0.03166479
p_int: 0.778950902
p_ni: 0.221049098
Score: 0.527
Data Source: BioPlex,STRINGDB
MRC2
Novelty: 0.01100289
p_int: 0.772932343
p_ni: 0.227067657
Score: 0.189
Data Source: BioPlex,STRINGDB
ATG2B
Novelty: 0.04963717
p_int: 0.762895117
p_ni: 0.237104682
p_wrong: 2.01e-7
Score: 0.67
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (37)
Reactome (17)
KEGG (4)
PathwayCommons (4)
UniProt (1)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 3 | 5 | 6 | 91.5 | |||||
mean platelet volume | 2 | 2 | 2 | 89.4 | |||||
intraocular pressure measurement | 2 | 3 | 3 | 89 | |||||
waist-hip ratio | 4 | 6 | 9 | 86.9 | |||||
2 | 2 | 1 | 6.6 | 82.1 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 6 | 91.5 | |||||
mean platelet volume | 2 | 89.4 | |||||
intraocular pressure measurement | 3 | 89 | |||||
waist-hip ratio | 9 | 86.9 | |||||
1 | 6.6 | 82.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | transaldolase 1 | VGNC:991 | 450933 | |||||
Mouse | MGI:1274789 | 21351 | ||||||
Rat | RGD:620674 | 83688 | ||||||
Dog | transaldolase | 475937 | ||||||
Horse | transaldolase 1 | VGNC:23863 | 100055991 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | transaldolase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | transaldolase | |||||
Horse | transaldolase 1 | |||||
Publication Statistics
PubMed Score 484.09
PubMed score by year
PubTator Score 340.10
PubTator score by year
Related Publications
Text Mined References (39)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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