Protein Summary
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the acti ...more
- ENST00000278968
- ENSP00000278968
- ENSG00000149591
- ENST00000392951
- ENSP00000376678
- ENST00000525531
- ENSP00000432054
- ENST00000530649
- ENSP00000431941
- ENST00000532870
- ENSP00000432282
- SM22
- WS3-10
- SM22
- SMCC
- TAGLN1
- WS3-10
- SM22-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.99 | ||
PubMedID | 0.97 | ||
transcription factor perturbation | 0.91 | ||
small molecule perturbation | 0.86 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 460.24 (req: < 5)
Gene RIFs: 73 (req: <= 3)
Antibodies: 635 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 460.24 (req: >= 5)
Gene RIFs: 73 (req: > 3)
Antibodies: 635 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0