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Tbio
TAGAP
T-cell activation Rho GTPase-activating protein

Protein Summary
Description
May function as a GTPase-activating protein and may play important roles during T-cell activation. This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326965
  • ENSP00000322650
  • ENSG00000164691
  • ENST00000338313
  • ENSP00000340217
  • ENST00000367066
  • ENSP00000356033

Symbol
  • TAGAP1
  • FKSG15
  • IDDM21
  • TAGAP1
  • ARHGAP47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.74
virus perturbation
0.72
cell type or tissue
0.7
phenotype
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.02   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.02   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0