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Tbio
TAF7
Transcription initiation factor TFIID subunit 7

Protein Summary
Description
Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313368
  • ENSP00000312709
  • ENSG00000178913

Symbol
  • TAF2F
  • TAFII55
  • TAF2F
  • TAFII55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
biological process
0.94
disease perturbation
0.87
histone modification site profile
0.82
molecular function
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (155)
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.999999923
p_ni:  7.7e-8
Data Source:  BioPlex
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999762
p_ni:  2.38e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.999999159
p_ni:  8.41e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRAC
Tdark
p_int:  0.999982888
p_ni:  0.00001711
p_wrong:  3e-9
Data Source:  BioPlex
IL20RA
Tbio
Novelty:  0.02416816
p_int:  0.991659523
p_ni:  0.008340477
Score:  0.183
Data Source:  BioPlex,STRINGDB
C8A
Tbio
Novelty:  0.00429321
p_int:  0.99128154
p_ni:  0.008571334
p_wrong:  0.000147126
Data Source:  BioPlex
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.975989141
p_ni:  0.024009631
p_wrong:  0.000001227
Data Source:  BioPlex
NXPH2
Tdark
Novelty:  0.65790631
p_int:  0.931079781
p_ni:  0.068920219
p_wrong:  1e-9
Score:  0.227
Data Source:  BioPlex,STRINGDB
FAM153B
Tdark
Novelty:  4.34922003
p_int:  0.906429016
p_ni:  0.092106237
p_wrong:  0.001464747
Score:  0.239
Data Source:  BioPlex,STRINGDB
TAF1
Tchem
Family:  Kinase
Novelty:  0.00555929
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
38.8
mean platelet volume
2
1
2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
38.8
mean platelet volume
2
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1346348
24074
Rat
RGD:1309935
307485
Dog
TATA-box binding protein associated factor 7
VGNC:47087
487180
Cow
TATA-box binding protein associated factor 7
VGNC:35579
509327
Pig
TATA-box binding protein associated factor 7
100523236
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
TATA-box binding protein associated factor 7
Cow
TATA-box binding protein associated factor 7
Pig
TATA-box binding protein associated factor 7
Publication Statistics
PubMed Score 17.17
PubMed score by year
PubTator Score 22.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title