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Tdark
TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

Protein Summary
Description
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a compo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294168
  • ENSP00000294168
  • ENSG00000162227

Symbol
  • PAF65A
  • PAF65A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
disease perturbation
0.83
cell type or tissue
0.79
molecular function
0.76
kinase perturbation
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.04   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.04   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
TADA1
Tdark
Novelty:  0.09903801
p_int:  0.999999971
p_ni:  2.9e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  0.999999293
p_ni:  7.07e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
ATXN7
Tbio
Novelty:  0.00323014
p_int:  0.999996547
p_ni:  0.000003407
p_wrong:  4.6e-8
Score:  0.969
Data Source:  BioPlex,STRINGDB
SUPT7L
Tdark
Novelty:  0.20661559
p_int:  0.999991924
p_ni:  0.000008009
p_wrong:  6.7e-8
Score:  0.988
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.999991313
p_ni:  0.000008687
Score:  0.993
Data Source:  BioPlex,STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
p_int:  0.999991007
p_ni:  0.000008821
p_wrong:  1.73e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
SUPT3H
Tbio
Novelty:  0.13202683
p_int:  0.999988463
p_ni:  0.000011516
p_wrong:  2.1e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
TAF9B
Tbio
Novelty:  0.0285313
p_int:  0.999984371
p_ni:  0.000015629
Score:  0.995
Data Source:  BioPlex,STRINGDB
TAF5L
Tbio
Family:  Enzyme
Novelty:  0.29525944
p_int:  0.999973335
p_ni:  0.000026665
Score:  0.997
Data Source:  BioPlex,STRINGDB
KAT2A
Tchem
Family:  Epigenetic
Novelty:  0.00238831
p_int:  0.999944457
p_ni:  0.000055543
Score:  0.988
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
26.6
BMI-adjusted waist-hip ratio
1
1
1
15.8
waist-hip ratio
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
26.6
BMI-adjusted waist-hip ratio
1
15.8
waist-hip ratio
1
14.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 6 like
VGNC:3054
451264
Macaque
TATA-box binding protein associated factor 6 like
722233
Mouse
MGI:2444957
225895
Rat
RGD:1310123
309194
Dog
TATA-box binding protein associated factor 6 like
VGNC:47086
476051
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 6 like
Macaque
TATA-box binding protein associated factor 6 like
Mouse
Rat
Dog
TATA-box binding protein associated factor 6 like
Publication Statistics
PubMed Score 1.04
PubMed score by year
PubTator Score 0.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title