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Tbio
TAF6
Transcription initiation factor TFIID subunit 6

Protein Summary
Description
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Isoform 4: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344095
  • ENSP00000344537
  • ENSG00000106290
  • ENST00000437822
  • ENSP00000399982
  • ENST00000452041
  • ENSP00000416396
  • ENST00000453269
  • ENSP00000389575

Symbol
  • TAF2E
  • TAFII70
  • ALYUS
  • TAF2E
  • TAFII70
  • TAFII80
  • TAFII85
  • MGC:8964
  • TAFII-70
  • TAFII-80
  • TAF(II)70
  • TAF(II)80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
protein complex
0.94
protein domain
0.73
tissue sample
0.66
virus
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.07   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.07   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0