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Tbio
TAF6
Transcription initiation factor TFIID subunit 6

Protein Summary
Description
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Isoform 4: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344095
  • ENSP00000344537
  • ENSG00000106290
  • ENST00000437822
  • ENSP00000399982
  • ENST00000452041
  • ENSP00000416396
  • ENST00000453269
  • ENSP00000389575

Symbol
  • TAF2E
  • TAFII70
  • ALYUS
  • TAF2E
  • TAFII70
  • TAFII80
  • TAFII85
  • MGC:8964
  • TAFII-70
  • TAFII-80
  • TAF(II)70
  • TAF(II)80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
protein complex
0.94
protein domain
0.73
tissue sample
0.66
virus
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.05   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.05   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (175)
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.999999825
p_ni:  1.75e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TAF7L
Tbio
Novelty:  0.08132691
p_int:  0.999999678
p_ni:  3.18e-7
p_wrong:  3e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999302
p_ni:  2.09e-7
p_wrong:  4.89e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.99999888
p_ni:  7.62e-7
p_wrong:  3.58e-7
Data Source:  BioPlex
RFC4
Tbio
Novelty:  0.03232586
p_int:  0.890855774
p_ni:  0.109143469
p_wrong:  7.57e-7
Score:  0.251
Data Source:  BioPlex,STRINGDB
TAF5
Tbio
Novelty:  0.05443551
Score:  0.999
Data Source:  STRINGDB
TAF11
Tchem
Novelty:  0.10299251
Score:  0.999
Data Source:  STRINGDB
TAF4
Tbio
Novelty:  0.02101584
Score:  0.999
Data Source:  STRINGDB
TAF2
Tbio
Novelty:  0.0397428
Score:  0.999
Data Source:  STRINGDB
TAF1
Tchem
Family:  Kinase
Novelty:  0.00555929
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
78.3
FEV/FEC ratio
1
1
1
62.5
body height
1
1
1
62.1
1
1
0
1.3
61
1
1
0
1.1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
78.3
FEV/FEC ratio
1
62.5
body height
1
62.1
0
1.3
61
0
1.1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 6
VGNC:8768
463588
Macaque
TATA-box binding protein associated factor 6
710863
Mouse
MGI:109129
21343
Rat
RGD:1311608
288533
Dog
TATA-box binding protein associated factor 6
VGNC:47085
489846
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 6
Macaque
TATA-box binding protein associated factor 6
Mouse
Rat
Dog
TATA-box binding protein associated factor 6
Publication Statistics
PubMed Score 22.05
PubMed score by year
PubTator Score 19.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title