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Tbio
TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

Protein Summary
Description
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258281
  • ENSP00000258281
  • ENSG00000135801
  • ENST00000366675
  • ENSP00000355635
  • ENST00000366676
  • ENSP00000355636

Symbol
  • PAF65B
  • PAF65B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
protein domain
0.85
microRNA
0.79
transcription factor binding site profile
0.79
interacting protein
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.97   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.97   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  0.999999973
p_ni:  2.7e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999739
p_ni:  2.61e-7
Score:  0.987
Data Source:  BioPlex,STRINGDB
SUPT20H
Tbio
Novelty:  0.00625899
p_int:  0.999999393
p_ni:  6.07e-7
Score:  0.967
Data Source:  BioPlex,STRINGDB
TADA1
Tdark
Novelty:  0.09903801
p_int:  0.999997819
p_ni:  0.000002181
Score:  0.99
Data Source:  BioPlex,STRINGDB
TAF6L
Tdark
Family:  Enzyme
Novelty:  0.7411477
p_int:  0.999973335
p_ni:  0.000026665
Score:  0.997
Data Source:  BioPlex,STRINGDB
ATXN7L3
Tbio
Novelty:  0.1572083
p_int:  0.999971321
p_ni:  0.000028679
Score:  0.992
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.999914135
p_ni:  0.000085865
Score:  0.991
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999864861
p_ni:  0.000135133
p_wrong:  6e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
HFE
Tbio
Novelty:  0.00042077
p_int:  0.998603469
p_ni:  0.001396529
p_wrong:  2e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
TAF9B
Tbio
Novelty:  0.0285313
p_int:  0.997966618
p_ni:  0.002033343
p_wrong:  3.9e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
6
2
4
1.1
92.2
mean corpuscular volume
1
1
1
67.3
mean reticulocyte volume
1
1
1
63.7
glucose measurement
3
1
3
62.3
mean corpuscular hemoglobin concentration
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
4
1.1
92.2
mean corpuscular volume
1
67.3
mean reticulocyte volume
1
63.7
glucose measurement
3
62.3
mean corpuscular hemoglobin concentration
1
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 5 like
VGNC:7003
457807
Macaque
TATA-box binding protein associated factor 5 like
693770
Mouse
MGI:1919039
102162
Rat
RGD:1310215
307927
Dog
TATA-box binding protein associated factor 5 like
VGNC:47084
488982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 5 like
Macaque
TATA-box binding protein associated factor 5 like
Mouse
Rat
Dog
TATA-box binding protein associated factor 5 like
Publication Statistics
PubMed Score 3.97
PubMed score by year
PubTator Score 2.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title