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Tbio
TAF5
Transcription initiation factor TFIID subunit 5

Protein Summary
Description
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369839
  • ENSP00000358854
  • ENSG00000148835

Symbol
  • TAF2D
  • TAF2D
  • TAFII100
  • TAFII-100
  • TAF(II)100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.94
protein domain
0.92
transcription factor perturbation
0.88
transcription factor binding site profile
0.79
molecular function
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.63   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.63   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.999999908
p_ni:  9.2e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999643
p_ni:  3.57e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TAF7L
Tbio
Novelty:  0.08132691
p_int:  0.999999409
p_ni:  5.91e-7
Score:  0.991
Data Source:  BioPlex,STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.99999932
p_ni:  6.8e-7
Data Source:  BioPlex
MCAT
Tbio
Family:  Enzyme
Novelty:  0.00600508
p_int:  0.998744199
p_ni:  0.001255801
Score:  0.274
Data Source:  BioPlex,STRINGDB
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.789443132
p_ni:  0.21055686
p_wrong:  8e-9
Score:  0.206
Data Source:  BioPlex,STRINGDB
TAF11
Tchem
Novelty:  0.10299251
Score:  0.999
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.999
Data Source:  STRINGDB
TAF7
Tbio
Novelty:  0.05316615
Score:  0.999
Data Source:  STRINGDB
TAF1
Tchem
Family:  Kinase
Novelty:  0.00555929
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
2
71.1
body height
1
1
1
69.2
intracranial volume measurement
1
1
0
6
35
cortical surface area measurement
1
1
0
495.5
31.4
worry measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
71.1
body height
1
69.2
intracranial volume measurement
0
6
35
cortical surface area measurement
0
495.5
31.4
worry measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 5
VGNC:5804
735428
Macaque
TATA-box binding protein associated factor 5
714558
Mouse
MGI:2442144
226182
Rat
RGD:1311332
294018
Dog
TATA-box binding protein associated factor 5
VGNC:47083
100688981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 5
Macaque
TATA-box binding protein associated factor 5
Mouse
Rat
Dog
TATA-box binding protein associated factor 5
Publication Statistics
PubMed Score 14.63
PubMed score by year
PubTator Score 14.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title