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Tbio
TAF4B
Transcription initiation factor TFIID subunit 4B

Protein Summary
Description
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269142
  • ENSP00000269142
  • ENSG00000141384
  • ENST00000418698
  • ENSP00000389365

Symbol
  • TAF2C2
  • TAFII105
  • SPGF13
  • TAF2C2
  • TAFII105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
cellular component
0.81
histone modification site profile
0.76
microRNA
0.62
small molecule perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999988
p_ni:  1e-8
p_wrong:  2e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.999999955
p_ni:  4.5e-8
Score:  0.977
Data Source:  BioPlex,STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.999999658
p_ni:  3.1e-7
p_wrong:  3.3e-8
Data Source:  BioPlex
TAF7L
Tbio
Novelty:  0.08132691
p_int:  0.999999121
p_ni:  8.07e-7
p_wrong:  7.2e-8
Score:  0.994
Data Source:  BioPlex,STRINGDB
TAF11
Tchem
Novelty:  0.10299251
Score:  0.997
Data Source:  STRINGDB
TAF1
Tchem
Family:  Kinase
Novelty:  0.00555929
Score:  0.997
Data Source:  STRINGDB
TAF7
Tbio
Novelty:  0.05316615
Score:  0.996
Data Source:  STRINGDB
TAF5
Tbio
Novelty:  0.05443551
Score:  0.991
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.991
Data Source:  STRINGDB
TAF6
Tbio
Novelty:  0.04357176
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (48)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
2
2
42.8
red blood cell density measurement
1
1
1
41.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
42.8
red blood cell density measurement
1
41.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 4b
VGNC:5210
455347
Macaque
TATA-box binding protein associated factor 4b
710168
Mouse
MGI:2152345
72504
Rat
RGD:1562997
291773
Dog
TATA-box binding protein associated factor 4b
VGNC:47082
490507
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 4b
Macaque
TATA-box binding protein associated factor 4b
Mouse
Rat
Dog
TATA-box binding protein associated factor 4b
Publication Statistics
PubMed Score 1.19
PubMed score by year
PubTator Score 15.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title