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Tbio
TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

Protein Summary
Description
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341690
  • ENSP00000345305
  • ENSG00000103168
  • ENST00000541676
  • ENSP00000437900
  • ENST00000566732
  • ENSP00000455933
  • ENST00000567759
  • ENSP00000455265
  • ENST00000570117
  • ENSP00000455247

Symbol
  • SL1
  • TAFI95
  • TAFI110
  • MGC:39976
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.84
transcription factor binding site profile
0.79
virus perturbation
0.76
gene perturbation
0.66
histone modification site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.81   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.81   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
TAF1D
Tdark
Family:  Enzyme
Novelty:  0.26072519
p_int:  0.999574357
p_ni:  0.000425642
p_wrong:  1e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999219205
p_ni:  0.000780793
p_wrong:  2e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
TAF1B
Tbio
Family:  Enzyme
Novelty:  0.10174314
p_int:  0.999029985
p_ni:  0.000970015
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.998391245
p_ni:  0.001608755
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.990106828
p_ni:  0.009893162
p_wrong:  1.1e-8
Data Source:  BioPlex
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.985863924
p_ni:  0.014136076
Score:  0.632
Data Source:  BioPlex,STRINGDB
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.983497652
p_ni:  0.016502348
Data Source:  BioPlex
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.982094638
p_ni:  0.017905361
Data Source:  BioPlex
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.981195196
p_ni:  0.018804802
p_wrong:  3e-9
Score:  0.194
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.979279571
p_ni:  0.02072043
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
33.8
mathematical ability
1
1
1
25.8
glomerular filtration rate
1
1
1
20.5
self reported educational attainment
1
1
1
12.1
gut microbiome measurement
1
1
1
11.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
33.8
mathematical ability
1
25.8
glomerular filtration rate
1
20.5
self reported educational attainment
1
12.1
gut microbiome measurement
1
11.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:109576
21341
Rat
RGD:1305658
361420
Dog
TATA-box binding protein associated factor, RNA polymerase I subunit C
VGNC:47079
609622
Horse
TATA-box binding protein associated factor, RNA polymerase I subunit C
VGNC:23849
100055972
Cow
TATA-box binding protein associated factor, RNA polymerase I subunit C
VGNC:35571
509238
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
TATA-box binding protein associated factor, RNA polymerase I subunit C
Horse
TATA-box binding protein associated factor, RNA polymerase I subunit C
Cow
TATA-box binding protein associated factor, RNA polymerase I subunit C
Publication Statistics
PubMed Score 8.81
PubMed score by year
PubTator Score 52.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title