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Tbio
TAF15
TATA-binding protein-associated factor 2N

Protein Summary
Description
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000604841
  • ENSP00000474609
  • ENSG00000270647
  • ENST00000605844
  • ENSP00000474096
  • ENST00000617382
  • ENSP00000480040
  • ENSG00000276833
  • ENST00000631482
  • ENSP00000488684

Symbol
  • RBP56
  • TAF2N
  • Npl3
  • RBP56
  • TAF2N
  • TAFII68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.9
gene perturbation
0.74
tissue
0.73
histone modification site profile
0.72


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.45   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.45   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
DNPEP
Tchem
Family:  Enzyme
Novelty:  0.02415651
p_int:  0.999158423
p_ni:  0.000841577
Score:  0.269
Data Source:  BioPlex,STRINGDB
KLHL8
Tdark
Novelty:  0.4838314
p_int:  0.998216355
p_ni:  0.001783596
p_wrong:  4.9e-8
Score:  0.206
Data Source:  BioPlex,STRINGDB
PRMT1
Tchem
Family:  Epigenetic
Novelty:  0.0032916
p_int:  0.916430928
p_ni:  0.083569072
Score:  0.706
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.982
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.973
Data Source:  STRINGDB
TAF12
Tbio
Novelty:  0.04352637
Score:  0.967
Data Source:  STRINGDB
TAF5
Tbio
Novelty:  0.05443551
Score:  0.965
Data Source:  STRINGDB
MATR3
Tbio
Novelty:  0.01218438
Score:  0.964
Data Source:  STRINGDB
TARDBP
Tchem
Novelty:  0.00165455
Score:  0.963
Data Source:  STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
4
97.3
mean platelet volume
3
4
4
97.3
reticulocyte count
5
4
9
90.5
reticulocyte count
5
4
9
90.5
CCL5 measurement
2
2
2
86.3
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
97.3
mean platelet volume
4
97.3
reticulocyte count
9
90.5
reticulocyte count
9
90.5
CCL5 measurement
2
86.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1917689
70439
Rat
RGD:1309595
287571
Dog
TATA-box binding protein associated factor 15
VGNC:47076
491135
Opossum
TATA-box binding protein associated factor 15
100021097
Chicken
TATA-box binding protein associated factor 15
CGNC:50532
417522
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
TATA-box binding protein associated factor 15
Opossum
TATA-box binding protein associated factor 15
Chicken
TATA-box binding protein associated factor 15
Publication Statistics
PubMed Score 20.45
PubMed score by year
PubTator Score 50.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title