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Tbio
TADA3
Transcriptional adapter 3

Protein Summary
Description
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301964
  • ENSP00000307684
  • ENSG00000171148
  • ENST00000343450
  • ENSP00000343649
  • ENST00000440161
  • ENSP00000393471

Symbol
  • ADA3
  • TADA3L
  • ADA3
  • NGG1
  • hADA3
  • STAF54
  • TADA3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
hub protein
0.85
biological process
0.8
transcription factor binding site profile
0.8
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.99   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.99   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
TADA2B
Tbio
Family:  TF
Novelty:  0.06387677
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
MBIP
Tbio
Novelty:  0.05807454
p_int:  1
Score:  0.988
Data Source:  BioPlex,STRINGDB
TADA2A
Tbio
Family:  TF
Novelty:  0.07665459
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
p_int:  0.999999889
p_ni:  6.4e-8
p_wrong:  4.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
KAT14
Tbio
Novelty:  0.17168043
p_int:  0.999999751
p_ni:  2.49e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
YEATS2
Tbio
Novelty:  0.17584498
p_int:  0.999998546
p_ni:  0.000001454
Score:  0.994
Data Source:  BioPlex,STRINGDB
KAT2A
Tchem
Family:  Epigenetic
Novelty:  0.00238831
p_int:  0.999998141
p_ni:  0.000001859
Score:  0.999
Data Source:  BioPlex,STRINGDB
TADA1
Tdark
Novelty:  0.09903801
p_int:  0.99999809
p_ni:  0.00000191
Score:  0.998
Data Source:  BioPlex,STRINGDB
ZZZ3
Tdark
Family:  TF
Novelty:  0.23862921
p_int:  0.999996761
p_ni:  0.000003239
Score:  0.982
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcriptional adaptor 3
VGNC:2598
460154
Macaque
transcriptional adaptor 3
700090
Mouse
MGI:1915724
101206
Rat
RGD:1564009
362414
Dog
transcriptional adaptor 3
VGNC:47072
476541
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcriptional adaptor 3
Macaque
transcriptional adaptor 3
Mouse
Rat
Dog
transcriptional adaptor 3
Publication Statistics
PubMed Score 57.99
PubMed score by year
PubTator Score 38.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title