Tbio TADA2B Transcriptional adapter 2-beta

Protein Summary

Description

Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]

Uniprot Accession IDs

• Q86TJ2
• A0AUJ8
• A4QMR7
• B3KSN0
• B3KU86
• Q6MZG9

Gene Name

• TADA2B

Ensembl ID

• ENST00000310074
• ENSP00000308022
• ENSG00000173011
• ENST00000512388
• ENSP00000423947
• ENST00000515646
• ENSP00000423181

Symbol

• ADA2B
• ADA2B
• ADA2(beta)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
microRNA	0.81
protein domain	0.73
tissue sample	0.63
histone modification site profile	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.57   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.57   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0