Tbio TACO1 Translational activator of cytochrome c oxidase 1

Protein Summary

Description

Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q9BSH4
• B2RD21
• Q8N3N6
• Q9UI60

Gene Name

• TACO1

Ensembl ID

• ENST00000258975
• ENSP00000258975
• ENSG00000136463

Symbol

• CCDC44
• CCDC44

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
transcription factor binding site profile	0.9
protein domain	0.73
cell line	0.58
virus perturbation	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.85   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.85   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0