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Tbio
TACC1
Transforming acidic coiled-coil-containing protein 1

Protein Summary
Description
Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276520
  • ENSP00000276520
  • ENSG00000147526
  • ENST00000317827
  • ENSP00000321703
  • ENST00000518415
  • ENSP00000428706
  • ENST00000520615
  • ENSP00000428450

Symbol
  • KIAA1103
  • Ga55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
kinase perturbation
0.84
ligand (protein) perturbation
0.83
transcription factor
0.76
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.38   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.38   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
TACC2
Tbio
Novelty:  0.05063528
p_int:  1
Score:  0.635
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999999438
p_ni:  3.4e-8
p_wrong:  5.28e-7
Score:  0.172
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999998999
p_ni:  0.000001001
Score:  0.165
Data Source:  BioPlex,STRINGDB
FSD2
Tbio
Novelty:  0.1302271
p_int:  0.999973706
p_ni:  0.000026294
p_wrong:  1e-9
Data Source:  BioPlex
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
p_int:  0.999917728
p_ni:  0.000082252
p_wrong:  2e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
p_int:  0.999909518
p_ni:  0.000090075
p_wrong:  4.08e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
POC1B
Tbio
Novelty:  0.09023863
p_int:  0.999672723
p_ni:  0.000296035
p_wrong:  0.000031242
Data Source:  BioPlex
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999646939
p_ni:  0.000317683
p_wrong:  0.000035378
Data Source:  BioPlex
KNSTRN
Tbio
Novelty:  0.05283444
p_int:  0.995818959
p_ni:  0.004180769
p_wrong:  2.72e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.994738554
p_ni:  0.005260372
p_wrong:  0.000001074
Score:  0.191
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
1
1
0
7.2
46.3
monocyte count
1
1
1
30.9
cortical surface area measurement
1
1
0
6
22.8
cortical thickness
1
1
0
5.9
21.6
hair color
1
1
0
1.1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
0
7.2
46.3
monocyte count
1
30.9
cortical surface area measurement
0
6
22.8
cortical thickness
0
5.9
21.6
hair color
0
1.1
11.1
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming acidic coiled-coil containing protein 1
VGNC:7601
464124
Macaque
transforming acidic coiled-coil containing protein 1
706243
Mouse
MGI:2443510
320165
Rat
RGD:1303120
306562
Dog
transforming acidic coiled-coil containing protein 1
VGNC:47063
475581
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming acidic coiled-coil containing protein 1
Macaque
transforming acidic coiled-coil containing protein 1
Mouse
Rat
Dog
transforming acidic coiled-coil containing protein 1
Publication Statistics
PubMed Score 32.38
PubMed score by year
PubTator Score 19.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title