Tchem TAB1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Protein Summary

Description

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15750
• Q2PP09
• Q8IZW2

Gene Name

• TAB1

Ensembl ID

• ENST00000216160
• ENSP00000216160
• ENSG00000100324
• ENST00000331454
• ENSP00000333049

Symbol

• MAP3K7IP1
• 3'-Tab1
• MAP3K7IP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.94
biological process	0.9
transcription factor	0.9
transcription factor binding site profile	0.84
pathway	0.81

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Tgf-beta-activated Kinase 1 And Map3k7-binding Protein 1

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / Tgf-beta-activated Kinase 1 And Map3k7-binding Protein 1

DTO Classes

Protein / Kinase / Unclassified Protein / Tgf-beta-activated Kinase 1 And Map3k7-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.38   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 573   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.38   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 573   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0