Tbio TAAR5 Trace amine-associated receptor 5

Protein Summary

Description

Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

Uniprot Accession IDs

• O14804
• D8KZS1
• Q2M1V1
• Q4VBL1
• Q5VUQ3
• Q6NTA8
• TaR-5

Gene Name

• TAAR5

Ensembl ID

• ENST00000258034
• ENSP00000258034
• ENSG00000135569

Symbol

• PNR
• PNR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.52
tissue	0.46
cell line	0.43
chemical	0.42
gene perturbation	0.42

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Trace Amine-associated Receptor 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.9   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 210   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.9   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0