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Tbio
SZT2
KICSTOR complex protein SZT2

Protein Summary
Description
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity). The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372450
  • ENSP00000361528
  • ENSG00000198198
  • ENST00000562955
  • ENSP00000457168
  • ENST00000634258
  • ENSP00000489255

Symbol
  • C1orf84
  • KIAA0467
  • SZT2A
  • SZT2B
  • EIEE18
  • C1orf84
  • KIAA0467
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
histone modification site profile
0.84
tissue sample
0.69
cellular component
0.68
cell line
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
BMT2
Tbio
Family:  Enzyme
Novelty:  0.05916379
p_int:  0.999999943
p_ni:  5.7e-8
Score:  0.828
Data Source:  BioPlex,Reactome,STRINGDB
ITFG2
Tbio
Novelty:  0.41720651
p_int:  0.999999629
p_ni:  3.71e-7
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
KPTN
Tbio
Novelty:  0.06841936
p_int:  0.999999416
p_ni:  5.84e-7
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
DEPDC5
Tbio
Novelty:  0.0177511
p_int:  0.999958755
p_ni:  0.000041245
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
C1QTNF2
Tbio
Novelty:  0.18607978
p_int:  0.99972199
p_ni:  0.00027801
Score:  0.666
Data Source:  BioPlex,STRINGDB
TSGA10IP
Tdark
Novelty:  20.75428866
p_int:  0.995803932
p_ni:  0.004196053
p_wrong:  1.5e-8
Data Source:  BioPlex
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.769247601
p_ni:  0.230373922
p_wrong:  0.000378477
Data Source:  BioPlex
WDR59
Tdark
Novelty:  0.22243351
Score:  0.997
Data Source:  STRINGDB
SEH1L
Tbio
Novelty:  0.03666501
Score:  0.996
Data Source:  STRINGDB
MIOS
Tdark
Novelty:  0.04252507
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
4
4
92.3
self reported educational attainment
3
3
2
6.6
92
platelet crit
2
3
4
88.5
cognitive function measurement
3
3
4
86.7
smoking status measurement
2
1
2
82.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
92.3
self reported educational attainment
2
6.6
92
platelet crit
4
88.5
cognitive function measurement
4
86.7
smoking status measurement
2
82.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SZT2, KICSTOR complex subunit
702661
Mouse
MGI:3033336
230676
Rat
RGD:1308616
362573
Dog
SZT2, KICSTOR complex subunit
VGNC:47057
482532
Horse
SZT2, KICSTOR complex subunit
VGNC:23833
100066517
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SZT2, KICSTOR complex subunit
Mouse
Rat
Dog
SZT2, KICSTOR complex subunit
Horse
SZT2, KICSTOR complex subunit
Publication Statistics
PubMed Score 15.20
PubMed score by year
PubTator Score 9.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title