Tbio SYTL2 Synaptotagmin-like protein 2

Protein Summary

Description

Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]

Uniprot Accession IDs

• Q9HCH5
• B3KRS3
• B4DJT5
• B4DKW3
• B4DQ26
• B7SA85
• B7ZLX6
• B7ZLX7
• Q2YDA7
• Q6TV07
• Q6ZN59
• Q6ZVC5
• Q8ND34
• Q96BJ2
• Q9H768
• Q9NXM1

Gene Name

• SYTL2

Ensembl ID

• ENST00000316356
• ENSP00000318803
• ENSG00000137501
• ENST00000359152
• ENSP00000352065
• ENST00000389958
• ENSP00000374608
• ENST00000389960
• ENSP00000374610
• ENST00000524452
• ENSP00000435238
• ENST00000525702
• ENSP00000432996
• ENST00000527523
• ENSP00000434010
• ENST00000528231
• ENSP00000431701
• ENST00000529581
• ENSP00000435855
• ENST00000533892
• ENSP00000432144

Symbol

• KIAA1597
• SGA72M
• SLP2
• SLP2A
• EXO4
• SLP2
• SLP2A
• SGA72M
• CHR11SYT
• PPP1R151

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
small molecule perturbation	0.89
gene perturbation	0.84
transcription factor perturbation	0.84
cellular component	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.47   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.47   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0