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Tbio
SYT4
Synaptotagmin-4

Protein Summary
Description
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255224
  • ENSP00000255224
  • ENSG00000132872
  • ENST00000590752
  • ENSP00000466930

Symbol
  • KIAA1342
  • HsT1192
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.72
cellular component
0.7
molecular function
0.63
PubMedID
0.6
gene perturbation
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.83   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.83   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.918
Data Source:  STRINGDB
CPLX1
Tbio
Novelty:  0.01434543
Score:  0.891
Data Source:  STRINGDB
PCSK2
Tchem
Family:  Enzyme
Novelty:  0.00611421
Score:  0.865
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.832
Data Source:  STRINGDB
STX1B
Tbio
Novelty:  0.01171833
Score:  0.828
Data Source:  STRINGDB
STX3
Tbio
Novelty:  0.01055819
Score:  0.817
Data Source:  STRINGDB
SYN2
Tbio
Novelty:  0.00574709
Score:  0.778
Data Source:  STRINGDB
SYN1
Tbio
Novelty:  0.00093242
Score:  0.77
Data Source:  STRINGDB
P58400
Tbio
Novelty:  0.00454659
Score:  0.757
Data Source:  STRINGDB
Q9ULB1
Tbio
Novelty:  0.00454659
Score:  0.757
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (50)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
11.2
waist-hip ratio
1
1
1
10.4
physical activity measurement
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
11.2
waist-hip ratio
1
10.4
physical activity measurement
1
3.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin 4
VGNC:5209
468526
Macaque
synaptotagmin 4
694191
Mouse
MGI:101759
20983
Rat
RGD:68397
64440
Dog
synaptotagmin 4
VGNC:47047
490474
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin 4
Macaque
synaptotagmin 4
Mouse
Rat
Dog
synaptotagmin 4
Publication Statistics
PubMed Score 64.83
PubMed score by year
PubTator Score 18.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title