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Tbio
SYT3
Synaptotagmin-3

Protein Summary
Description
Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338916
  • ENSP00000340914
  • ENSG00000213023
  • ENST00000593901
  • ENSP00000468982
  • ENST00000600079
  • ENSP00000469398

Symbol
  • SytIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.76
cell type or tissue
0.65
molecular function
0.63
tissue sample
0.58
tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.73   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.73   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
SYT6
Tbio
Novelty:  0.03549215
p_int:  0.999999999
p_ni:  1e-9
Score:  0.86
Data Source:  BioPlex,STRINGDB
SYT10
Tbio
Novelty:  0.03869283
p_int:  0.999999821
p_ni:  1e-9
p_wrong:  1.79e-7
Score:  0.857
Data Source:  BioPlex,STRINGDB
MYH4
Tbio
Novelty:  0.00556982
p_int:  0.999570661
p_ni:  0.000429338
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
FNDC3A
Tbio
Novelty:  0.04721453
p_int:  0.999160495
p_ni:  0.000839041
p_wrong:  4.64e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
MYH7
Tclin
Novelty:  0.00268092
p_int:  0.996462723
p_ni:  0.00337035
p_wrong:  0.000166926
Score:  0.187
Data Source:  BioPlex,STRINGDB
MADD
Tbio
Family:  Enzyme
Novelty:  0.01590443
p_int:  0.971027641
p_ni:  0.028972358
p_wrong:  1e-9
Score:  0.8
Data Source:  BioPlex,STRINGDB
PGK2
Tbio
Family:  Kinase
Novelty:  0.00832045
p_int:  0.961901175
p_ni:  0.03809881
p_wrong:  1.5e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
LMF2
Tbio
Family:  Enzyme
Novelty:  0.24810125
p_int:  0.76747387
p_ni:  0.232396314
p_wrong:  0.000129816
Score:  0.166
Data Source:  BioPlex,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.881
Data Source:  STRINGDB
CPLX1
Tbio
Novelty:  0.01434543
Score:  0.738
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
2
3
74.7
smoking status measurement
2
1
2
40.7
body height
1
1
1
34.9
body mass index
1
1
1
25.8
electrocardiography
1
1
1
20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
74.7
smoking status measurement
2
40.7
body height
1
34.9
body mass index
1
25.8
electrocardiography
1
20
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin 3
VGNC:3585
456233
Mouse
MGI:99665
20981
Rat
RGD:3805
25731
Dog
synaptotagmin 3
VGNC:47046
484360
Horse
synaptotagmin 3
VGNC:23821
100062910
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin 3
Mouse
Rat
Dog
synaptotagmin 3
Horse
synaptotagmin 3
Publication Statistics
PubMed Score 37.73
PubMed score by year
PubTator Score 9.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title