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Tbio
SYT12
Synaptotagmin-12

Protein Summary
Description
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393946
  • ENSP00000377520
  • ENSG00000173227
  • ENST00000525457
  • ENSP00000431400
  • ENST00000527043
  • ENSP00000435316

Symbol
  • SYT11
  • sytXII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.73
gene perturbation
0.71
cell type or tissue
0.7
virus perturbation
0.64
transcription factor
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.04   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.04   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
PDK2
Tchem
Family:  Kinase
Novelty:  0.01502257
p_int:  0.999999044
p_ni:  9.55e-7
Score:  0.657
Data Source:  BioPlex,STRINGDB
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.99999219
p_ni:  0.00000781
Data Source:  BioPlex
HTT
Tchem
Novelty:  0.00034051
p_int:  0.999970299
p_ni:  0.000029701
Score:  0.249
Data Source:  BioPlex,STRINGDB
PDK3
Tchem
Family:  Kinase
Novelty:  0.05009442
p_int:  0.999384651
p_ni:  0.000615349
Score:  0.288
Data Source:  BioPlex,STRINGDB
MADD
Tbio
Family:  Enzyme
Novelty:  0.01590443
p_int:  0.99841559
p_ni:  0.00158441
Score:  0.238
Data Source:  BioPlex,STRINGDB
CCDC77
Tdark
Novelty:  2.54727442
p_int:  0.998289258
p_ni:  0.000202763
p_wrong:  0.001507979
Score:  0.188
Data Source:  BioPlex,STRINGDB
ENTPD7
Tbio
Family:  Enzyme
Novelty:  0.1810079
p_int:  0.99738597
p_ni:  0.001322127
p_wrong:  0.001291902
Data Source:  BioPlex
NXPE3
Tdark
Novelty:  1.5063521
p_int:  0.996838439
p_ni:  0.003161533
p_wrong:  2.8e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
MFAP3
Tdark
Novelty:  0.55512255
p_int:  0.996270276
p_ni:  0.00372971
p_wrong:  1.4e-8
Data Source:  BioPlex
ZNF445
Tdark
Family:  TF
Novelty:  0.43307505
p_int:  0.993960195
p_ni:  0.006039805
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Neurexins and neuroligins (R-HSA-6794361)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
4
6
94
body fat distribution
2
1
4
81.5
red blood cell density measurement
1
1
1
79.9
BMI-adjusted hip circumference
2
3
4
78.4
body height
3
2
3
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
6
94
body fat distribution
4
81.5
red blood cell density measurement
1
79.9
BMI-adjusted hip circumference
4
78.4
body height
3
74.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
synaptotagmin 12
721773
Mouse
MGI:2159601
171180
Rat
RGD:621876
191595
Dog
synaptotagmin 12
VGNC:47043
483703
Horse
synaptotagmin 12
VGNC:23818
100052905
Species
Name
OMA
EggNOG
Inparanoid
Macaque
synaptotagmin 12
Mouse
Rat
Dog
synaptotagmin 12
Horse
synaptotagmin 12
Publication Statistics
PubMed Score 24.04
PubMed score by year
PubTator Score 3.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title