Tbio SYT1 Synaptotagmin-1

Protein Summary

Description

May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003). The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]

Uniprot Accession IDs

• P21579
• Q6AI31

Gene Name

• SYT1

Ensembl ID

• ENST00000261205
• ENSP00000261205
• ENSG00000067715
• ENST00000393240
• ENSP00000376932
• ENST00000552744
• ENSP00000447575

Symbol

• SVP65
• SYT
• P65
• SYT
• BAGOS
• SVP65

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
molecular function	0.94
trait	0.93
gene perturbation	0.91
hub protein	0.82

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Synaptotagmin-1

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Synaptotagmin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 683.11   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 768   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 683.11   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0