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Tdark
SYPL2
Synaptophysin-like protein 2

Protein Summary
Description
Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369872
  • ENSP00000358888
  • ENSG00000143028

Symbol
  • MG29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.7
cell type or tissue
0.69
cellular component
0.64
tissue
0.61
PubMedID
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.25   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.25   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
TMEM192
Tbio
Novelty:  0.30699087
p_int:  0.99931425
p_ni:  0.00068575
Data Source:  BioPlex
TMEM120A
Tdark
Novelty:  0.21664358
p_int:  0.996844981
p_ni:  0.00315336
p_wrong:  0.000001659
Score:  0.189
Data Source:  BioPlex,STRINGDB
MFSD12
Tbio
Novelty:  0.20519777
p_int:  0.987631013
p_ni:  0.003175793
p_wrong:  0.009193194
Score:  0.289
Data Source:  BioPlex,STRINGDB
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.978616897
p_ni:  0.021383103
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
NECTIN2
Tbio
Novelty:  0.00910836
p_int:  0.973993129
p_ni:  0.026006871
Score:  0.163
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.949351546
p_ni:  0.050648454
Data Source:  BioPlex
GCA
Tbio
Novelty:  0.01485875
p_int:  0.908438023
p_ni:  0.089101756
p_wrong:  0.00246022
Score:  0.219
Data Source:  BioPlex,STRINGDB
TSPAN15
Tbio
Novelty:  0.16947672
p_int:  0.894421321
p_ni:  0.105298285
p_wrong:  0.000280394
Score:  0.181
Data Source:  BioPlex,STRINGDB
RTN2
Tbio
Novelty:  0.05184418
p_int:  0.824553455
p_ni:  0.175388983
p_wrong:  0.000057561
Score:  0.181
Data Source:  BioPlex,STRINGDB
VAMP3
Tbio
Novelty:  0.00694332
p_int:  0.785043624
p_ni:  0.214956319
p_wrong:  5.7e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
11
11
98.3
low density lipoprotein cholesterol measurement
2
10
11
96.8
body mass index
7
3
8
94.3
total cholesterol measurement
1
7
7
92.5
self reported educational attainment
4
4
3
6.3
90.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
11
98.3
low density lipoprotein cholesterol measurement
11
96.8
body mass index
8
94.3
total cholesterol measurement
7
92.5
self reported educational attainment
3
6.3
90.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1328311
17306
Rat
RGD:1309907
362018
Dog
synaptophysin like 2
VGNC:54075
611827
Horse
synaptophysin like 2
VGNC:23814
100061523
Cow
synaptophysin like 2
VGNC:54496
514665
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
synaptophysin like 2
Horse
synaptophysin like 2
Cow
synaptophysin like 2
Publication Statistics
PubMed Score 28.25
PubMed score by year
PubTator Score 10.00
PubTator score by year
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Related Publications
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PMID
Year
Title