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Tbio
SYP
Synaptophysin

Protein Summary
Description
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263233
  • ENSP00000263233
  • ENSG00000102003
  • ENST00000479808
  • ENSP00000418169

Symbol
  • MRX96
  • MRXSYP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.78
chemical
0.74
kinase
0.72
cell type or tissue
0.7
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4335.29   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 1128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4335.29   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 1128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (362)
TMEM183A
Tdark
Novelty:  0.4017284
p_int:  0.999895254
p_ni:  0.000099867
p_wrong:  0.000004878
Score:  0.319
Data Source:  BioPlex,STRINGDB
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
p_int:  0.999790986
p_ni:  0.000003907
p_wrong:  0.000205106
Score:  0.203
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999497035
p_ni:  0.000196789
p_wrong:  0.000306176
Data Source:  BioPlex
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999497035
p_ni:  0.000196789
p_wrong:  0.000306176
Data Source:  BioPlex
SLC25A23
Tbio
Family:  Transporter
Novelty:  0.10446757
p_int:  0.999055555
p_ni:  0.000944312
p_wrong:  1.33e-7
Score:  0.156
Data Source:  BioPlex,STRINGDB
MRS2
Tbio
Novelty:  0.00264753
p_int:  0.997940383
p_ni:  0.002059617
Data Source:  BioPlex
SLC35B2
Tbio
Family:  Transporter
Novelty:  0.01516638
p_int:  0.991311263
p_ni:  0.008678446
p_wrong:  0.000010291
Score:  0.167
Data Source:  BioPlex,STRINGDB
SFXN3
Tbio
Novelty:  0.18698456
p_int:  0.987916718
p_ni:  0.006530752
p_wrong:  0.00555253
Score:  0.161
Data Source:  BioPlex,STRINGDB
SLC20A2
Tbio
Family:  Transporter
Novelty:  0.00387767
p_int:  0.985182401
p_ni:  0.009305476
p_wrong:  0.005512123
Data Source:  BioPlex
SLC25A16
Tbio
Family:  Transporter
Novelty:  0.00778831
p_int:  0.984187348
p_ni:  0.015812652
Score:  0.157
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Synaptic Vesicle Pathway
WikiPathways
Synaptic Vesicle Pathway
WikiPathways
Insulin Signaling
Name
Explore in Pharos
Explore in Source
Synaptic Vesicle Pathway
Synaptic Vesicle Pathway
Insulin Signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
46.1
childhood onset asthma
1
1
0
1
38.2
mean platelet volume
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
46.1
childhood onset asthma
0
1
38.2
mean platelet volume
1
13.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptophysin
VGNC:11628
465628
Macaque
synaptophysin
715739
Mouse
MGI:98467
20977
Rat
RGD:3802
24804
Dog
synaptophysin
VGNC:54605
612557
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptophysin
Macaque
synaptophysin
Mouse
Rat
Dog
synaptophysin
Publication Statistics
PubMed Score 4335.29
PubMed score by year
PubTator Score 1808.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title