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Tdark
SYNRG
Synergin gamma

Protein Summary
Description
May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins. This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610513
  • ENSP00000478707
  • ENSG00000274047
  • ENST00000612223
  • ENSP00000483453
  • ENSG00000275066
  • ENST00000613407
  • ENSP00000483152
  • ENST00000614941
  • ENSP00000481151
  • ENST00000616179
  • ENSP00000482962
  • ENST00000618176
  • ENSP00000482597
  • ENST00000618402
  • ENSP00000480288
  • ENST00000619541
  • ENSP00000477885
  • ENST00000621136
  • ENSP00000484529
  • ENST00000622045
  • ENSP00000483063
  • ENST00000632841
  • ENSP00000487672
  • ENST00000633429
  • ENSP00000488473

Symbol
  • AP1GBP1
  • SYNG
  • SYNG
  • AP1GBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor binding site profile
0.79
transcription factor
0.78
cellular component
0.75
histone modification site profile
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0