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Tbio
SYNPO
Synaptopodin

Protein Summary
Description
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307662
  • ENSP00000302139
  • ENSG00000171992
  • ENST00000394243
  • ENSP00000377789
  • ENST00000519664
  • ENSP00000429268
  • ENST00000522122
  • ENSP00000428378

Symbol
  • KIAA1029
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
cellular component
0.86
ligand (protein) perturbation
0.83
microRNA
0.76
transcription factor
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.17   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.17   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
NPHS2
Tbio
Novelty:  0.00212981
Score:  0.892
Data Source:  STRINGDB
NPHS1
Tbio
Novelty:  0.00104742
Score:  0.875
Data Source:  STRINGDB
MAGI1
Tbio
Family:  Enzyme
Novelty:  0.06837323
Score:  0.841
Data Source:  STRINGDB
CD2AP
Tbio
Novelty:  0.00603034
Score:  0.825
Data Source:  STRINGDB
WT1
Tbio
Family:  TF
Novelty:  0.00034353
Score:  0.799
Data Source:  STRINGDB
ACTN4
Tbio
Novelty:  0.0040236
Score:  0.788
Data Source:  STRINGDB
PODXL
Tbio
Novelty:  0.00306913
Score:  0.767
Data Source:  STRINGDB
SCEL
Tbio
Novelty:  0.03037518
Score:  0.711
Data Source:  STRINGDB
PTPRO
Tbio
Family:  Enzyme
Novelty:  0.01613645
Score:  0.67
Data Source:  STRINGDB
SULF1
Tbio
Family:  Enzyme
Novelty:  0.00992209
Score:  0.654
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
52.4
neutrophil count
1
1
1
33.1
Non-steroidal anti-inflammatory and antirheumatic product use measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
52.4
neutrophil count
1
33.1
Non-steroidal anti-inflammatory and antirheumatic product use measurement
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptopodin
VGNC:13604
471697
Macaque
synaptopodin
711221
Mouse
MGI:1099446
104027
Rat
RGD:620668
60324
Dog
synaptopodin
VGNC:47034
479327
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptopodin
Macaque
synaptopodin
Mouse
Rat
Dog
synaptopodin
Publication Statistics
PubMed Score 203.17
PubMed score by year
PubTator Score 41.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title