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Tchem
SYNJ1
Synaptojanin-1

Protein Summary
Description
Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). This gene encodes a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357345
  • ENSP00000349903
  • ENSG00000159082

Symbol
  • KIAA0910
  • EIEE53
  • INPP5G
  • PARK20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.84
microRNA
0.82
histone modification site profile
0.81
biological process
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.7   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.7   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (275)
SNX9
Tbio
Novelty:  0.01737783
p_int:  0.999999961
p_ni:  2e-9
p_wrong:  3.6e-8
Score:  0.981
Data Source:  BioPlex,STRINGDB
ALKBH2
Tbio
Family:  Enzyme
Novelty:  0.02318716
p_int:  0.999999683
p_ni:  3.17e-7
Score:  0.252
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999993155
p_ni:  0.000006816
p_wrong:  2.8e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.945530307
p_ni:  0.000211477
p_wrong:  0.054258216
Score:  0.564
Data Source:  BioPlex,STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.996
Data Source:  STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.99
Data Source:  STRINGDB
SH3GL2
Tbio
Novelty:  0.0188955
Score:  0.987
Data Source:  STRINGDB
AMPH
Tbio
Novelty:  0.00201043
Score:  0.984
Data Source:  STRINGDB
SH3GL1
Tbio
Novelty:  0.02379336
Score:  0.979
Data Source:  STRINGDB
SNAP91
Tbio
Novelty:  0.0083886
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (80)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Inositol phosphate metabolism
Reactome
Membrane Trafficking
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Inositol phosphate metabolism
Membrane Trafficking
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.9
31.4
age at onset
1
1
0
5.9
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.9
31.4
age at onset
0
5.9
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptojanin 1
VGNC:1122
473959
Macaque
synaptojanin 1
707829
Mouse
MGI:1354961
104015
Rat
RGD:69434
85238
Dog
synaptojanin 1
VGNC:47032
478403
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptojanin 1
Macaque
synaptojanin 1
Mouse
Rat
Dog
synaptojanin 1
Publication Statistics
PubMed Score 101.70
PubMed score by year
PubTator Score 44.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title