Protein Summary
May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication. This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
- ENST00000225777
- ENSP00000225777
- ENSG00000108639
- ENST00000585591
- ENSP00000465678
- ENST00000588282
- ENSP00000467600
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
disease perturbation | 0.93 | ||
virus perturbation | 0.85 | ||
transcription factor perturbation | 0.8 | ||
gene perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.76 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 242 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.76 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 242 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (47)
GPR52
Family: GPCR
Novelty: 0.07988639
p_int: 0.975167835
p_ni: 0.024832164
p_wrong: 1e-9
Data Source: BioPlex
VIPR2
Family: GPCR
Novelty: 0.00463802
p_int: 0.973155169
p_ni: 0.026844831
Data Source: BioPlex
PCDHAC2
Novelty: 0.28397695
p_int: 0.973072158
p_ni: 0.026927841
p_wrong: 1e-9
Data Source: BioPlex
SLC22A9
Family: Transporter
Novelty: 0.02212992
p_int: 0.957475299
p_ni: 0.042524701
Data Source: BioPlex
SLC34A2
Family: Transporter
Novelty: 0.00601743
p_int: 0.938761479
p_ni: 0.061238521
Score: 0.15
Data Source: BioPlex,STRINGDB
ADGRE5
Family: GPCR
Novelty: 0.01137558
p_int: 0.933819022
p_ni: 0.066180977
Data Source: BioPlex
SLCO1B1
Family: Transporter
Novelty: 0.00126613
p_int: 0.932512915
p_ni: 0.06746861
p_wrong: 0.000018475
Score: 0.181
Data Source: BioPlex,STRINGDB
TACR1
Family: GPCR
Novelty: 0.00062762
p_int: 0.921099912
p_ni: 0.078900088
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Components (6)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations (null)
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
HbA1c measurement | 9 | 16 | 20 | 99.7 | |||||
mean corpuscular volume | 3 | 5 | 5 | 98.4 | |||||
red blood cell distribution width | 4 | 6 | 10 | 98.1 | |||||
reticulocyte measurement | 3 | 7 | 11 | 95.8 | |||||
reticulocyte count | 7 | 11 | 24 | 95.8 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
HbA1c measurement | 20 | 99.7 | |||||
mean corpuscular volume | 5 | 98.4 | |||||
red blood cell distribution width | 10 | 98.1 | |||||
reticulocyte measurement | 11 | 95.8 | |||||
reticulocyte count | 24 | 95.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | synaptogyrin 2 | 709310 | ||||||
Rat | RGD:621334 | 89815 | ||||||
Dog | synaptogyrin 2 | 100687829 | ||||||
Cow | synaptogyrin 2 | 513812 | ||||||
Platypus | synaptogyrin 2 | 100092423 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | synaptogyrin 2 | |||||
Rat | ||||||
Dog | synaptogyrin 2 | |||||
Cow | synaptogyrin 2 | |||||
Platypus | synaptogyrin 2 | |||||
Publication Statistics
PubMed Score 9.76
PubMed score by year
PubTator Score 5.27
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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