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Tbio
SYNGR2
Synaptogyrin-2

Protein Summary
Description
May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication. This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225777
  • ENSP00000225777
  • ENSG00000108639
  • ENST00000585591
  • ENSP00000465678
  • ENST00000588282
  • ENSP00000467600
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
virus perturbation
0.85
transcription factor perturbation
0.8
gene perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
GPR52
Tchem
Family:  GPCR
Novelty:  0.07988639
p_int:  0.975167835
p_ni:  0.024832164
p_wrong:  1e-9
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.973155169
p_ni:  0.026844831
Data Source:  BioPlex
PCDHAC2
Tdark
Novelty:  0.28397695
p_int:  0.973072158
p_ni:  0.026927841
p_wrong:  1e-9
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.957475299
p_ni:  0.042524701
Data Source:  BioPlex
SLC34A2
Tchem
Family:  Transporter
Novelty:  0.00601743
p_int:  0.938761479
p_ni:  0.061238521
Score:  0.15
Data Source:  BioPlex,STRINGDB
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.933819022
p_ni:  0.066180977
Data Source:  BioPlex
SLCO1B1
Tchem
Family:  Transporter
Novelty:  0.00126613
p_int:  0.932512915
p_ni:  0.06746861
p_wrong:  0.000018475
Score:  0.181
Data Source:  BioPlex,STRINGDB
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.921099912
p_ni:  0.078900088
Data Source:  BioPlex
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.912360039
p_ni:  0.08763996
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.911794664
p_ni:  0.088205326
p_wrong:  1e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
9
16
20
99.7
mean corpuscular volume
3
5
5
98.4
red blood cell distribution width
4
6
10
98.1
reticulocyte measurement
3
7
11
95.8
reticulocyte count
7
11
24
95.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
20
99.7
mean corpuscular volume
5
98.4
red blood cell distribution width
10
98.1
reticulocyte measurement
11
95.8
reticulocyte count
24
95.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
synaptogyrin 2
709310
Rat
RGD:621334
89815
Dog
synaptogyrin 2
100687829
Cow
synaptogyrin 2
513812
Platypus
synaptogyrin 2
100092423
Species
Name
OMA
EggNOG
Inparanoid
Macaque
synaptogyrin 2
Rat
Dog
synaptogyrin 2
Cow
synaptogyrin 2
Platypus
synaptogyrin 2
Publication Statistics
PubMed Score 9.76
PubMed score by year
PubTator Score 5.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title