Tbio SYNGAP1 Ras/Rap GTPase-activating protein SynGAP

Protein Summary

Description

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Uniprot Accession IDs

• Q96PV0
• A2AB17
• A2BEL6
• A2BEL7
• A8MQC4
• Q8TCS2
• Q9UGE2

Gene Name

• SYNGAP1

Ensembl ID

• ENST00000395071
• ENSP00000378509
• ENSG00000227460
• ENST00000414753
• ENSP00000407995
• ENST00000418600
• ENSP00000403636
• ENSG00000197283
• ENST00000428982
• ENSP00000412475
• ENST00000455687
• ENSP00000414259
• ENST00000628646
• ENSP00000486431
• ENST00000629380
• ENSP00000486463
• ENST00000646630
• ENSP00000496007

Symbol

• KIAA1938
• MRD5
• RASA1
• RASA5
• SYNGAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
biological process	0.83
cell type or tissue	0.61
tissue sample	0.61
cell line	0.58

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Ras/rap Gtpase-activating Protein Syngap

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Ras/rap Gtpase-activating Protein Syngap

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.1   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 218   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.1   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0