You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SYNGAP1
Ras/Rap GTPase-activating protein SynGAP

Protein Summary
Description
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity). This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein int ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395071
  • ENSP00000378509
  • ENSG00000227460
  • ENST00000414753
  • ENSP00000407995
  • ENST00000418600
  • ENSP00000403636
  • ENSG00000197283
  • ENST00000428982
  • ENSP00000412475
  • ENST00000455687
  • ENSP00000414259
  • ENST00000628646
  • ENSP00000486431
  • ENST00000629380
  • ENSP00000486463
  • ENST00000646630
  • ENSP00000496007

Symbol
  • KIAA1938
  • MRD5
  • RASA1
  • RASA5
  • SYNGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.83
cell type or tissue
0.61
tissue sample
0.61
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.1   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.1   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0