You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SYNE4
Nesprin-4

Protein Summary
Description
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324444
  • ENSP00000316130
  • ENSG00000181392
  • ENST00000340477
  • ENSP00000343152
  • ENST00000645695
  • ENSP00000496471

Symbol
  • C19orf46
  • KASH4
  • Nesp4
  • DFNB76
  • C19orf46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.76
gene perturbation
0.74
tissue sample
0.54
cell type or tissue
0.49
histone modification site profile
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.16   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.16   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
KLC3
Tbio
Novelty:  0.0528937
p_int:  0.99999999
p_ni:  8e-9
p_wrong:  2e-9
Score:  0.737
Data Source:  BioPlex,STRINGDB
KLC2
Tbio
Novelty:  0.06284367
p_int:  0.999999811
p_ni:  1.89e-7
Score:  0.597
Data Source:  BioPlex,STRINGDB
KLC4
Tdark
Novelty:  0.32552746
p_int:  0.9999996
p_ni:  4e-7
Score:  0.348
Data Source:  BioPlex,STRINGDB
KLC1
Tbio
Novelty:  0.00653484
p_int:  0.999999272
p_ni:  7.28e-7
Score:  0.687
Data Source:  BioPlex,STRINGDB
KIF5A
Tbio
Novelty:  0.01277095
p_int:  0.99999927
p_ni:  7.3e-7
p_wrong:  1e-9
Data Source:  BioPlex
KIF5C
Tbio
Novelty:  0.0238573
p_int:  0.999976112
p_ni:  0.000023888
Score:  0.219
Data Source:  BioPlex,STRINGDB
GOLIM4
Tbio
Novelty:  0.01923513
p_int:  0.999964397
p_ni:  0.000035594
p_wrong:  9e-9
Data Source:  BioPlex
KIF5B
Tbio
Novelty:  0.00515256
p_int:  0.999774657
p_ni:  0.000225343
Score:  0.694
Data Source:  BioPlex,STRINGDB
ZFPL1
Tbio
Novelty:  0.1829181
p_int:  0.999638545
p_ni:  0.000339947
p_wrong:  0.000021508
Data Source:  BioPlex
FZD3
Tbio
Family:  GPCR
Novelty:  0.00964507
p_int:  0.999377269
p_ni:  0.000353119
p_wrong:  0.000269612
Score:  0.198
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Envelope proteins and their potential roles in EDMD physiopathology
WikiPathways
Envelope proteins and their potential roles in EDMD physiopathology
WikiPathways
Envelope proteins and their potential roles in EDMD physiopathology
WikiPathways
Envelope proteins and their potential roles in EDMD physiopathology
WikiPathways
Envelope proteins and their potential roles in EDMD physiopathology
Name
Explore in Pharos
Explore in Source
Envelope proteins and their potential roles in EDMD physiopathology
Envelope proteins and their potential roles in EDMD physiopathology
Envelope proteins and their potential roles in EDMD physiopathology
Envelope proteins and their potential roles in EDMD physiopathology
Envelope proteins and their potential roles in EDMD physiopathology
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
1
1
0
1.1
33.1
educational attainment
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
0
1.1
33.1
educational attainment
1
0.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
spectrin repeat containing nuclear envelope family member 4
VGNC:10270
746096
Mouse
MGI:2141950
233066
Rat
RGD:1304580
292781
Dog
spectrin repeat containing nuclear envelope family member 4
VGNC:47030
612623
Horse
spectrin repeat containing nuclear envelope family member 4
VGNC:23803
100051801
Species
Name
OMA
EggNOG
Inparanoid
Chimp
spectrin repeat containing nuclear envelope family member 4
Mouse
Rat
Dog
spectrin repeat containing nuclear envelope family member 4
Horse
spectrin repeat containing nuclear envelope family member 4
Publication Statistics
PubMed Score 12.16
PubMed score by year
PubTator Score 4.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title